公开(公告)号：EP4253554A3

公开(公告)日：2024-01-17

申请号：EP23177116.3

申请日：2020-03-18

申请人： Janssen Pharmaceuticals, Inc. ,  GlaxoSmithKline Biologicals S.A.

发明人： GEURTSEN, Jeroen ,  BURGHOUT, Pieter, Jan ,  WEERDENBURG, Eveline, Marleen ,  POOLMAN, Jan, Theunis ,  FAE, Kellen, Cristhina ,  IBARRA YON, Patricia ,  ABBANAT, Darren, Robert ,  KEMMLER, Stefan, Jochen ,  KOWARIK, Michael, Thomas ,  MALLY, Manuela ,  GAMBILLARA FONCK, Veronica ,  BRAUN, Martin, Edward ,  CARRANZA SANDMEIER, Maria, Paula

IPC分类号： C12N9/10 ,  C12P21/00

摘要： Methods of producing bioconjugates of O-antigen polysaccharides covalently linked to a carrier protein using recombinant host cells are provided. The recombinant host cells used in the methods described herein encode a particular oligosaccharyl transferase enzyme depending on the O-antigen polysaccharide bioconjugate to be produced. The oligosaccharyl transferase enzymes can be PglB oligosaccharyl transferase or variants thereof. Also provided are compositions containing the bioconjugates, and methods of using the bioconjugates and compositions described herein to vaccinate a subject against extra-intestinal pathogenic E . coli. (ExPEC).

公开(公告)号：EP3942028A1

公开(公告)日：2022-01-26

申请号：EP20718990.3

申请日：2020-03-18

申请人： Janssen Pharmaceuticals, Inc. ,  GlaxoSmithKline Biologicals S.A.

发明人： GEURTSEN, Jeroen ,  BURGHOUT, Pieter, Jan ,  WEERDENBURG, Eveline, Marleen ,  POOLMAN, Jan, Theunis ,  FAE, Kellen, Cristhina ,  IBARRA YON, Patricia ,  ABBANAT, Darren, Robert ,  KEMMLER, Stefan, Jochen ,  KOWARIK, Michael, Thomas ,  MALLY, Manuela ,  GAMBILLARA, FONCK, Veronica ,  BRAUN, Martin, Edward ,  CARRANZA SANDMEIER, Maria, Paula

IPC分类号： C12N9/10 ,  C12P21/00

公开(公告)号：EP3341016A1

公开(公告)日：2018-07-04

申请号：EP16760616.9

申请日：2016-08-24

申请人： GlaxoSmithKline Biologicals S.A. ,  Janssen Pharmaceuticals, Inc.

发明人： POOLMAN, Jan, Theunis ,  JACQUEMYN, Bert ,  ABBANAT, Darren, Robert ,  YON, Patricia, Ibarra ,  HERMANS, Peter, Wilhelmus, Maria ,  KOWARIK, Michael, Thomas ,  WETTER, Michael, Lukas ,  KEMMLER, Stefan, Jochen ,  HAUPTLE, Micha, Andres ,  GAMBILLARA, Veronica ,  MALLY, Manuela

IPC分类号： A61K39/02 ,  C08B37/00 ,  A61K39/00 ,  A61K39/108

CPC分类号： A61K39/0258 ,  A61K39/385 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/545 ,  A61K2039/55583 ,  A61K2039/6037 ,  A61K2039/6087 ,  A61K2039/70 ,  A61P31/04 ,  C08B37/0063 ,  Y02A50/474

摘要： Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B, O1A, O2, and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, O2, O6A and O25B.

公开(公告)号：EP4253554A2

公开(公告)日：2023-10-04

申请号：EP23177116.3

申请日：2020-03-18

申请人： Janssen Pharmaceuticals, Inc. ,  GlaxoSmithKline Biologicals S.A.

发明人： GEURTSEN, Jeroen ,  BURGHOUT, Pieter, Jan ,  WEERDENBURG, Eveline, Marleen ,  POOLMAN, Jan, Theunis ,  FAE, Kellen, Cristhina ,  IBARRA YON, Patricia ,  ABBANAT, Darren, Robert ,  KEMMLER, Stefan, Jochen ,  KOWARIK, Michael, Thomas ,  MALLY, Manuela ,  GAMBILLARA FONCK, Veronica ,  BRAUN, Martin, Edward ,  CARRANZA SANDMEIER, Maria, Paula

IPC分类号： C12P21/00

摘要： Methods of producing bioconjugates of O-antigen polysaccharides covalently linked to a carrier protein using recombinant host cells are provided. The recombinant host cells used in the methods described herein encode a particular oligosaccharyl transferase enzyme depending on the O-antigen polysaccharide bioconjugate to be produced. The oligosaccharyl transferase enzymes can be PglB oligosaccharyl transferase or variants thereof. Also provided are compositions containing the bioconjugates, and methods of using the bioconjugates and compositions described herein to vaccinate a subject against extra-intestinal pathogenic E . coli. (ExPEC).

公开(公告)号：EP3941516A1

公开(公告)日：2022-01-26

申请号：EP20718989.5

申请日：2020-03-18

申请人： Janssen Pharmaceuticals, Inc. ,  GlaxoSmithKline Biologicals S.A.

发明人： GEURTSEN, Jeroen ,  POOLMAN, Jan, Theunis ,  FAE, Kellen, Cristhina ,  BURGHOUT, Pieter, Jan ,  WEERDENBURG, Eveline, Marleen ,  IBARRA YON, Patricia ,  ABBANAT, Darren, Robert ,  KEMMLER, Stefan, Jochen ,  KOWARIK, Michael, Thomas ,  MALLY, Manuela ,  GAMBILLARA FONCK, Veronica ,  BRAUN, Martin, Edward ,  CARRANZA SANDMEIER, Maria, Paula

IPC分类号： A61K39/108 ,  A61P13/02

公开(公告)号：EP4213870A1

公开(公告)日：2023-07-26

申请号：EP21772844.3

申请日：2021-09-17

申请人： Janssen Pharmaceuticals, Inc.

发明人： POOLMAN, Jan, Theunis ,  FAE, Kellen, Cristhina ,  SARNECKI, Michal ,  GEURTSEN, Jeroen ,  ABBANAT, Darren, Robert ,  SPIESSENS, Bart, Gustaaf, M. ,  STRUYF, Frank, Germaine, F.

IPC分类号： A61K39/108 ,  A61P13/00 ,  A61P31/04