公开(公告)号：EP2277533B1

公开(公告)日：2016-07-20

申请号：EP10163236.2

申请日：2003-10-22

申请人： GlaxoSmithKline Biologicals S.A. ,  The United States of America as represented by The Secretary of The Navy

发明人： Hoffman, Stephen L. ,  Wang, Ruobing ,  Epstein, Judith E. ,  Cohen, Joseph D.

IPC分类号： A61K39/015 ,  C07K14/445 ,  A61P33/06 ,  G01N33/53

CPC分类号： A61K39/015 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/57 ,  C07K14/445 ,  Y02A50/412 ,  Y02A50/58

摘要： The invention pertains to methods for protecting against malaria infection by vaccination. The method of the invention involves priming an anti-malaria immune response with a DNA-based vaccine, and boosting that response with a protein-based vaccine. The method of the invention also relates to broadening the resulting immune response by boosting with a protein-based vaccine.

公开(公告)号：EP2277533A3

公开(公告)日：2012-03-07

申请号：EP10163236.2

申请日：2003-10-22

申请人： GlaxoSmithKline Biologicals S.A. ,  The United States of America as represented by The Secretary of The Navy

发明人： Hoffman, Stephen L. ,  Wang, Ruobing ,  Epstein, Judith E. ,  Cohen, Joseph D.

IPC分类号： A61K39/015 ,  C07K14/445 ,  A61P33/06 ,  G01N33/53

CPC分类号： A61K39/015 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/57 ,  C07K14/445 ,  Y02A50/412 ,  Y02A50/58

摘要： The invention pertains to methods for protecting against malaria infection by vaccination. The method of the invention involves priming an anti-malaria immune response with a DNA-based vaccine, and boosting that response with a protein-based vaccine. The method of the invention also relates to broadening the resulting immune response by boosting with a protein-based vaccine.

公开(公告)号：EP2277533A2

公开(公告)日：2011-01-26

申请号：EP10163236.2

申请日：2003-10-22

申请人： GlaxoSmithKline Biologicals s.a. ,  The United States of America as represented by The Secretary of The Navy

发明人： Hoffman, Stephen L. ,  Wang, Ruobing ,  Epstein, Judith E. ,  Cohen, Joseph D.

IPC分类号： A61K39/015 ,  C07K14/445 ,  A61P33/06 ,  G01N33/53

CPC分类号： A61K39/015 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/57 ,  C07K14/445 ,  Y02A50/412 ,  Y02A50/58

摘要： The invention pertains to methods for protecting against malaria infection by vaccination. The method of the invention involves priming an anti-malaria immune response with a DNA-based vaccine, and boosting that response with a protein-based vaccine. The method of the invention also relates to broadening the resulting immune response by boosting with a protein-based vaccine.

摘要翻译： 本发明涉及通过疫苗接种来防止疟疾感染的方法。 本发明的方法涉及用基于DNA的疫苗引发抗疟疾免疫应答，并用基于蛋白质的疫苗来提高该反应。 本发明的方法还涉及通过用基于蛋白质的疫苗进行加强来扩大产生的免疫应答。