专利检索 ap:("GlaxoSmithKline istrazivacki centar Zagreb d.o.o.") AND inv:"Rupcic, Renata" 第 1 页

1.

发明授权
1,3-DIAZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF 有权
标题翻译： 1.3二氮杂 - 二苯并如肿瘤坏死因子的产生才能产生抑制剂和中间产品

公开(公告)号：EP1509528B1

公开(公告)日：2008-09-24

申请号：EP03755236.1

申请日：2003-05-20

申请人： GlaxoSmithKline istrazivacki centar Zagreb d.o.o.

发明人： Mercep, Mladen , Mesic,Milan , Rupcic, Renata , Pesic, Dijana

IPC分类号： C07D491/04 , C07D495/04 , C07D487/04 , C07D235/02 , A61K31/55 , A61P29/00

CPC分类号： C07D491/04 , C07D495/04

摘要： The present invention relates to 1,3-diaza-dibenzoazulene derivatives of formula (I), to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-α (TNF-α) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.