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    METHODS AND COMPOSITIONS FOR TREATING ARTERIOSCLEROTIC VASCULAR DISEASES
    6.
    发明公开
    METHODS AND COMPOSITIONS FOR TREATING ARTERIOSCLEROTIC VASCULAR DISEASES 审中-公开
    治疗动脉粥样硬化性血管疾病的方法和组合物

    公开(公告)号：EP2830640A1

    公开(公告)日：2015-02-04

    申请号：EP13767875.1

    申请日：2013-03-26

    Applicant: Golden Biotechnology Corporation

    Inventor： LIU, Sheng-Yung ,  WEN, Wu-Che ,  CHEN, Chih-Ming

    IPC: A61K36/07

    CPC classification number: C07C49/753 ,  A61K9/0014 ,  A61K9/0031 ,  A61K9/0048 ,  A61K9/0056 ,  A61K9/0078 ,  A61K9/4858 ,  A61K31/122 ,  A61K31/133 ,  A61K36/07

    Abstract: The present invention provides methods and compositions for treating arteriosclerotic vascular diseases by cyclohexenone compounds. In some embodiments, the compound in the methods inhibits PDGF-stimulated smooth muscle cell proliferation or migration. In some embodiments, the atherosclerosis is associated with coronary artery disease, aneurysm, arteriosclerosis, myocardial infarction, embolism, stroke, thrombosis, angina, vascular plaque inflammation, vascular plaque rupture, Kawasaki disease, calcification or inflammation. In some embodiments, the compound lowers low-density lipoprotein (LDL) cholesterol in the subject. In some embodiments, the compound maintains a normal low-density lipoprotein (LDL) cholesterol level in the subject.

    Abstract translation: 本发明提供了通过环己烯酮化合物治疗动脉硬化性血管疾病的方法和组合物。 在一些实施方案中，所述方法中的化合物抑制PDGF-刺激的平滑肌细胞增殖或迁移。 在一些实施方案中，动脉粥样硬化与冠状动脉疾病，动脉瘤，动脉硬化，心肌梗塞，栓塞，中风，血栓形成，心绞痛，血管斑块炎症，血管斑块破裂，川崎病，钙化或炎症有关。 在一些实施方案中，该化合物降低受试者中的低密度脂蛋白（LDL）胆固醇。 在一些实施方案中，所述化合物在受试者中维持正常的低密度脂蛋白（LDL）胆固醇水平。

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