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公开(公告)号：EP1809321B1
公开(公告)日：2012-03-14
申请号：EP05858553.0
申请日：2005-10-07
IPC分类号： C12N5/0783
CPC分类号： C12N5/0636 , A61K2039/5156 , A61K2039/5158 , A61K2039/55527
摘要： The invention provides for compositions, e.g., pharmaceutical compositions, comprising a T lymphocyte, or a population thereof, expressing at least one recombinant polynucleotide encoding a cytokine that enhances T lymphocyte survival during the contraction phase of an immune response. The invention further provides an isolated T lymphocyte, or population thereof, expressing at least one recombinant polynucleotide encoding the cytokine, wherein the polynucleotide comprises a non-native coding sequence encoding the cytokine. Also provided is the use of such compositions and T lymphocytes, or populations thereof, for the treatment or prevention of a medical condition e.g., cancer. A method of preparing the a T lymphocyte with enhanced T cell survival is further provided herein.
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公开(公告)号：EP1809321A2
公开(公告)日：2007-07-25
申请号：EP05858553.0
申请日：2005-10-07
IPC分类号： A61K39/00
CPC分类号： C12N5/0636 , A61K2039/5156 , A61K2039/5158 , A61K2039/55527
摘要： The invention provides for compositions, e.g., pharmaceutical compositions, comprising a T lymphocyte, or a population thereof, expressing at least one recombinant polynucleotide encoding a cytokine that enhances T lymphocyte survival during the contraction phase of an immune response. The invention further provides an isolated T lymphocyte, or population thereof, expressing at least one recombinant polynucleotide encoding the cytokine, wherein the polynucleotide comprises a non-native coding sequence encoding the cytokine. Also provided is the use of such compositions and T lymphocytes, or populations thereof, for the treatment or prevention of a medical condition e.g., cancer. A method of preparing the a T lymphocyte with enhanced T cell survival is further provided herein.
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