专利检索 ap:("Government of the United States of America, Represented by the Secretary, Department of Health AND Human Services") AND inv:"RESTIFO, Nicholas P." 第 1 页

1.

发明授权
GP100-specific T cell receptors and related materials and methods of use 有权
标题翻译：具体GP100-T细胞受体和相应的材料和使用的方法

公开(公告)号：EP2102236B1

公开(公告)日：2014-08-06

申请号：EP08727582.2

申请日：2008-01-11

申请人： Government of the United States of America, Represented by the Secretary, Department of Health and Human Services

发明人： RESTIFO, Nicholas P. , CASSARD, Lydie , YU, Zhiya , ROSENBERG, Steven A.

IPC分类号： C07K14/705 , A61K38/17

CPC分类号： C07K14/70503 , A61K38/00 , C07K14/7051 , C07K16/30 , C12N15/85 , C12N15/86 , G01N33/57492

2.

发明公开
GP100-SPECIFIC T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USE 有权
标题翻译：具体GP100-T细胞受体和相应的材料和使用的方法

公开(公告)号：EP2102236A2

公开(公告)日：2009-09-23

申请号：EP08727582.2

申请日：2008-01-11

申请人： Government of the United States of America, Represented by the Secretary, Department of Health and Human Services

发明人： RESTIFO, Nicholas P. , CASSARD, Lydie , YU, Zhiya , ROSENBERG, Steven A.

IPC分类号： C07K14/725

CPC分类号： C07K14/70503 , A61K38/00 , C07K14/7051 , C07K16/30 , C12N15/85 , C12N15/86 , G01N33/57492

摘要： The invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino acids 154-162 of gp100 (SEQ ID NO: 1), as well as related polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding fragments thereof, conjugates, and pharmaceutical compositions, are further provided. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host comprising the use of the inventive materials described herein.