公开(公告)号：EP3985025A1

公开(公告)日：2022-04-20

申请号：EP20821874.3

申请日：2020-05-22

申请人： Green Cross Corporation ,  Mogam Institute for Biomedical Research

发明人： PARK, Hye-Young ,  SONG, Eun Jung ,  LEE, Eun Hee ,  YUM, Hye In ,  NAM, Hye Mi ,  KIM, Mun Kyung ,  LEE, Jee Won ,  SHEEN, Joong Hyuk ,  HUR, Min Kyu ,  LIM, So Jung ,  LIM, Ok Jae ,  LIM, Yang Mi ,  WON, Jong Hwa

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K39/00

摘要： The present invention relates to: an antibody to T cell Immunoreceptor with Ig and Tyrosine-Based Inhibitory Motif Domains (TIGIT), or an antigen-binding fragment thereof; a nucleic acid encoding same; a vector carrying the nucleic acid; a cell transformed with the vector; a method for producing the antibody or the antigen-binding fragment thereof; and a composition and a composition for combined administration, which comprise same and are for preventing or treating cancer.

公开(公告)号：EP3954711A1

公开(公告)日：2022-02-16

申请号：EP20788397.6

申请日：2020-04-06

申请人： Green Cross Corporation ,  Mogam Institute for Biomedical Research

发明人： PARK, Jae Chan ,  SONG, Eun Jung ,  LIM, So Jung ,  LEE, Jae-Chul ,  KWON, Hae Naem ,  LEE, Su A ,  LIM, Ok Jae ,  KIM, Mun Kyung ,  CHO, Hyun Jung ,  KIM, Gil-Jung ,  LEE, Jee Won ,  KIM, Sung Keun ,  WON, Jong Wha ,  JANG, Shin A

IPC分类号： C07K16/30 ,  C07K16/28 ,  A61P35/00

摘要： The present invention relates to a bispecific anti-GPNMB/anti-CD3 antibody specifically binding to CD3 and GPNMB, and the use thereof. Particularly, the bispecific antibody shows high affinity and specificity to CD3 and GPNMB and thus can induce death of cancer cells expressing GPNMB and inhibit proliferation thereof. Therefore, the bispecific antibody can be used as an effective therapeutic agent for cancers expressing GPNMB.