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公开(公告)号：EP1712242B1
公开(公告)日：2018-05-30
申请号：EP04807749.9
申请日：2004-12-24
申请人： Hagiwara, Masatoshi
IPC分类号： A61K45/00 , A61K31/4453 , A61K31/4545 , A61K31/455 , A61K31/5377 , A61K31/4409 , A61K31/4439 , A61K31/55 , C07D295/12 , C07D295/06 , C07D213/81 , C07D213/82 , C07D213/83 , C07D401/12 , A61P31/12 , C12Q1/48
CPC分类号： A61K31/444 , A61K31/4409 , A61K31/4439 , A61K31/4453 , A61K31/4545 , A61K31/455 , A61K31/5377 , A61K31/55 , C07D211/14 , C07D213/81 , C07D213/82 , C07D401/12 , C12N15/1137 , Y02A50/385 , Y02A50/389 , Y02A50/463 , Y02A50/465 , Y02A50/467
摘要： The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad-spectrum antiviral agents applicable to new viruses.
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2.发明公开METHOD OF REGULATING PHOSPHORYLATION OF SR PROTEIN AND ANTIVIRAL AGENTS COMPRISING SR PROTEIN ACTIVITY REGULATOR AS THE ACTIVE INGREDIENT 有权调节方法SR蛋白与SR蛋白质的活性调节剂AS含有活性抗病毒药物磷酸化
公开(公告)号：EP1712242A1
公开(公告)日：2006-10-18
申请号：EP04807749.9
申请日：2004-12-24
申请人： HAGIWARA, Masatoshi
IPC分类号： A61K45/00 , A61K31/4453 , A61K31/4545 , A61K31/455 , A61K31/5377 , A61K31/4409 , A61K31/4439 , A61K31/55 , C07D295/12 , C07D295/06 , C07D213/81 , C07D213/82 , C07D213/83 , C07D401/12 , A61P31/12 , C12Q1/48
CPC分类号： A61K31/444 , A61K31/4409 , A61K31/4439 , A61K31/4453 , A61K31/4545 , A61K31/455 , A61K31/5377 , A61K31/55 , C07D211/14 , C07D213/81 , C07D213/82 , C07D401/12 , C12N15/1137 , Y02A50/385 , Y02A50/389 , Y02A50/463 , Y02A50/465 , Y02A50/467
摘要： The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad-spectrum antiviral agents applicable to new viruses.
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