公开(公告)号：EP0820314A1

公开(公告)日：1998-01-28

申请号：EP96908962.0

申请日：1996-04-09

申请人： HAMILTON CIVIC HOSPITALS RESEARCH DEVELOPMENT, INC.

发明人： HIRSH, Jack ,  JOHNSTON, Marilyn ,  TEOH, Kevin

IPC分类号： A61L24 ,  A61K38 ,  C12N9

CPC分类号： C12N9/6429 ,  A61L24/106 ,  C12Y304/21005

摘要： A fibrin glue includes a fibrinogen component and a thrombin component, both prepared from single donor plasma. The plasma is precipitated to produce a precipitate containing fibrinogen and a supernatant containing the thrombin. The precipitate may be resuspended in a small volume of supernatant and used as the fibrinogen component. The supernatant is further treated by clotting to convert residual fibrinogen to fibrin and filtration to remove the fibrin. Optionally, at least a portion of the anti-thrombin III originally present in the supernatant may be removed to prolong thrombin activity therein. The resulting serum can be used as the thrombin component.