公开(公告)号：EP1663299A2

公开(公告)日：2006-06-07

申请号：EP04761661.0

申请日：2004-08-12

申请人： HAMILTON CIVIC HOSPITALS RESEARCH DEVELOPMENT, INC.

发明人： CHAN, Anthony, Kam, Chuen ,  KLEMENT, Petr ,  TRESSEL, Paul ,  BERRY, Leslie, Roy ,  WEITZ, Jeffrey, I. ,  HIRSH, Jack

IPC分类号： A61K38/55 ,  A61K31/726 ,  A61K31/727 ,  A61P7/02 ,  A61P9/10

CPC分类号： A61K31/726 ,  A61K38/57 ,  A61K47/61 ,  A61K2300/00

摘要： The present invention relates to therapeutic methods for preventing or reducing neurological events utilizing a glycosaminoglycan and a serpin, including complexes and conjugates thereof. Methods of the present invention may be advantageous for preventing or reducing neurological events prior to, or during medical or surgical procedures, and after a neurological event. In particular, the present invention deals with neurological events associated with the generation of emboli that can lodge in the brain and/or cerebral circulation during cardiac surgery.

公开(公告)号：EP1192187A1

公开(公告)日：2002-04-03

申请号：EP00941847.6

申请日：2000-06-29

申请人： HAMILTON CIVIC HOSPITALS RESEARCH DEVELOPMENT, INC.

发明人： WEITZ, Jeffrey, I. ,  HIRSH, Jack

IPC分类号： C08B37/10 ,  A61K31/727

CPC分类号： C08B37/0078 ,  A61K31/715 ,  A61K31/727 ,  A61K45/06

摘要： The present invention provides compositions and methods for the treatment of cardiovascular diseases. More particularly, the present invention relates to modifying thrombus formation by administering an agent which, inter alia, is capable of (1) inactivating fluid-phase thrombin and thrombin which is bound either to fibrin in a clot or to some other surface by catalyzing antithrombin; and (2) inhibiting thrombin generation by catalyzing factor Xa inactivation by antithrombin III (ATIII). The compositions and methods of the present invention are particularly useful for preventing thrombosis in the circuit of cardiac bypass apparatus and in patients undergoing renal dialysis, and for treating patients suffering from or at risk of suffering from thrombus-related cardiovascular conditions, such as unstable angina, acute myocardial infraction (heart attack), cerebrovascular accidents (stroke), pulmonary embolism, deep vein thrombosis, arterial thrombosis, etc.