公开(公告)号：EP1994163A2

公开(公告)日：2008-11-26

申请号：EP07753369.3

申请日：2007-03-16

申请人： HEALTH RESEARCH, INC. ,  Duke University

发明人： FERRONE, Soldano ,  WANG, Xinhui ,  CLAY, Tim ,  LYERLY, Kim, H. ,  MORSE, Michael, A. ,  DEVI, Gay ,  OSADA, Takuya

IPC分类号： C12P19/00

CPC分类号： G01N33/57415 ,  A61K51/1051 ,  A61K51/1066 ,  A61K2039/505 ,  C07K16/3015 ,  C07K16/3053

摘要： Disclosed is a method for inhibiting the growth of breast carcinoma stem cells, that express High Molecular Weight-Melanoma Associated Antigen (HMW-MAA). The method comprises administering to an individual a composition comprising an antibody reactive with HMW-MAA or a fragment of such an antibody in an amount effective to inhibit the growth of the breast carcinoma cells. Also provided are methods for inhibiting metastasis of breast carcinomas and methods for identifying HMW-MAA+ breast cancer stem cells.