公开(公告)号：EP0734722B1

公开(公告)日：2002-06-26

申请号：EP94902115.8

申请日：1993-12-14

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： YAMAGUCHI, Hisashi Tukuba Laboratory of Hisamitsu ,  MAEDA, Hiroyuki Tukuba Laboratory of Hisamitsu ,  KAMIHORIUCHI, Yoshirou Tukuba Laboratory of Hisam

IPC分类号： A61K9/70

CPC分类号： A61K9/703 ,  A61K9/7084

摘要： A percutaneous administration patch medicine used to administer the medicine to a human body through the skin or mucous membrane, consisting of: (1) a backing layer nonpermeable to medicine components; (2) a medicine storage layer positioned on the lower side of the central portion of the backing layer and containing medicine components; (3) a protective film positioned on the lower side of the medicine storage layer and the circumferential portion of the backing layer, having cuts and nonpermeable to the medicine components; (4) a pressure sensitive adhesive layer positioned on the lower side of the protective film; and (5) a separable liner layer positioned on the lower side of the pressure sensitive adhesive layer and nonpermeable to the medicine components; the percutaneous administration patch medicine being capable of effectively minimizing the leakage and volatilization of medicine until the medicine has been administered to a patient through the skin, and maintaining the stability of the medicine during the preservation thereof.

公开(公告)号：EP0734722A1

公开(公告)日：1996-10-02

申请号：EP94902115.8

申请日：1993-12-14

申请人： HISAMITSU PHARMACEUTICAL CO. INC.

发明人： YAMAGUCHI, Hisashi Tukuba Laboratory of Hisamitsu ,  MAEDA, Hiroyuki Tukuba Laboratory of Hisamitsu ,  KAMIHORIUCHI, Yoshirou Tukuba Laboratory of Hisam

IPC分类号： A61K9/70

CPC分类号： A61K9/703 ,  A61K9/7084

摘要： A percutaneous administration patch medicine used to administer the medicine to a human body through the skin or mucous membrane, consisting of: (1) a backing layer nonpermeable to medicine components; (2) a medicine storage layer positioned on the lower side of the central portion of the backing layer and containing medicine components; (3) a protective film positioned on the lower side of the medicine storage layer and the circumferential portion of the backing layer, having cuts and nonpermeable to the medicine components; (4) a pressure sensitive adhesive layer positioned on the lower side of the protective film; and (5) a separable liner layer positioned on the lower side of the pressure sensitive adhesive layer and nonpermeable to the medicine components; the percutaneous administration patch medicine being capable of effectively minimizing the leakage and volatilization of medicine until the medicine has been administered to a patient through the skin, and maintaining the stability of the medicine during the preservation thereof.

摘要翻译： 用于通过皮肤或粘膜将药物施用于人体的经皮给药补片药，由以下组成：（1）不能渗透药物成分的背衬层; （2）药物储存层，其位于背衬层的中心部分的下侧并且包含药物成分; （3）保护膜，其位于药物储存层的下侧和背衬层的周向部分上，具有切口并且不能渗透到药物成分中; （4）位于保护膜下侧的压敏粘合剂层; 和（5）位于所述压敏粘合剂层的下侧上并且不能渗透到所述药物成分的可分离衬垫层; 经皮给药补片药物能够有效地使药物的渗漏和挥发最小化，直到药物通过皮肤给药给患者，并且在保存药物期间保持药物的稳定性。