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1.发明公开Azacycloalkane derivatives, absorption promoters containing the derivatives as the effective ingredient and external preparation containing the absorption promoters 失效含有衍生物的吸收剂衍生物，含有衍生物作为有效成分和包含吸收促进剂的外部制剂
公开(公告)号：EP0241050A3
公开(公告)日：1988-12-28
申请号：EP87200183
申请日：1987-02-07
发明人： Tsuji, Masayoshi , Inoue, Hisataka , Hachiya, Terumi , Nakashima, Mikio , Saita, Masaru , Shimozono, Yuji , Nakagawa, Akira , Sakai, Michinori
IPC分类号： C07D207/27 , C07D211/76 , C07D223/10 , C07D263/18 , C07D265/30 , C07D267/10 , C07D277/14 , C07D279/12 , C07D281/06 , A61K47/00 , A01N25/32
CPC分类号： C07D207/267 , C07D207/27 , C07D211/76 , C07D223/10 , C07D263/18 , C07D265/32 , C07D277/14 , C07D279/12 , C07D281/06 , Y10S514/946
摘要： An azacycloalkane derivative useful for promoting the absorption of a medicine, an absorption promoting agent comprising at least one of the azacycloalkane derivatives as the effective ingredient for promoting the absorption and an external preparation containing the absorption promoting agent, the derivative being represented by the following formula
wherein A is -CH 2 -or -S-for example, B is sulfur or oxygen, R is -SR" in which R" is an alkyl group or alkylthioalkyl group for example, or -OR" in which R" is as defined above, an alkyl group or substituted amino group, R' is a hydrogen atom, alkyl group or alkyloxy group for example, m is an integer of 0-5 and n is an integer of 1-15.-
2.发明授权Azacycloalkane derivatives, absorption promoters containing the derivatives as the effective ingredient and external preparation containing the absorption promoters 失效亚胺卡因衍生物，含有衍生物的吸收促进剂作为有效成分和包含吸收促进剂的外部制剂
公开(公告)号：EP0241050B1
公开(公告)日：1992-10-14
申请号：EP87200183.9
申请日：1987-02-07
发明人： Tsuji, Masayoshi , Inoue, Hisataka , Hachiya, Terumi , Nakashima, Mikio , Saita, Masaru , Shimozono, Yuji , Nakagawa, Akira , Sakai, Michinori
IPC分类号： C07D207/27 , C07D211/76 , C07D223/10 , C07D263/18 , C07D265/30 , C07D267/10 , C07D277/14 , C07D279/12 , C07D281/06 , A61K47/00 , A01N25/32
CPC分类号： C07D207/267 , C07D207/27 , C07D211/76 , C07D223/10 , C07D263/18 , C07D265/32 , C07D277/14 , C07D279/12 , C07D281/06 , Y10S514/946
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3.发明公开Azacycloalkane derivatives, absorption promoters containing the derivatives as the effective ingredient and external preparation containing the absorption promoters 失效氮杂环烷烃衍生物，含有所述衍生物作为有效成分的吸收促进剂包括外用制剂，吸收促进剂。
公开(公告)号：EP0241050A2
公开(公告)日：1987-10-14
申请号：EP87200183.9
申请日：1987-02-07
发明人： Tsuji, Masayoshi , Inoue, Hisataka , Hachiya, Terumi , Nakashima, Mikio , Saita, Masaru , Shimozono, Yuji , Nakagawa, Akira , Sakai, Michinori
IPC分类号： C07D207/27 , C07D211/76 , C07D223/10 , C07D263/18 , C07D265/30 , C07D267/10 , C07D277/14 , C07D279/12 , C07D281/06 , A61K47/00 , A01N25/32
CPC分类号： C07D207/267 , C07D207/27 , C07D211/76 , C07D223/10 , C07D263/18 , C07D265/32 , C07D277/14 , C07D279/12 , C07D281/06 , Y10S514/946
摘要： An azacycloalkane derivative useful for promoting the absorption of a medicine, an absorption promoting agent comprising at least one of the azacycloalkane derivatives as the effective ingredient for promoting the absorption and an external preparation containing the absorption promoting agent, the derivative being represented by the following formula
wherein A is -CH 2 -or -S-for example, B is sulfur or oxygen, R is -SR" in which R" is an alkyl group or alkylthioalkyl group for example, or -OR" in which R" is as defined above, an alkyl group or substituted amino group, R' is a hydrogen atom, alkyl group or alkyloxy group for example, m is an integer of 0-5 and n is an integer of 1-15.摘要翻译： 在氮杂环烷烃衍生物可用于促销婷药物的吸收宣传片婷剂吸收包含的氮杂环烷烃衍生物作为促销婷吸收和外用制剂含有上述吸收宣传片婷剂的有效成分中的至少一个，所述衍生物是由下式表示
worin A是-CH 2 - 或-S-实施例，B是硫或氧，R是-SR“”，其中R“”是其中的烷基或烷硫基烷基，例如，或或“” R“”是如上所定义，以烷基或substituiertem氨基，R“是氢原子，烷基或烷氧基，例如，m是0-5的整数，n是1-15的整数。
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