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1.发明授权
公开(公告)号：EP1121941B1
公开(公告)日：2006-06-07
申请号：EP99947897.7
申请日：1999-10-14
发明人： IKEURA, Yasuhiro, Hisamitsu Pharmaceutical Co. Inc , MAKI, Masayoshi, Hisamitsu Pharmaceutical Co. Inc.
CPC分类号： A61K9/7053 , A61K9/0014 , A61K9/7076 , A61K31/565 , A61K31/57 , A61K47/10
摘要： Percutaneous sorbefacients comprising hexylene glycol and l-menthol, more particularly, percutaneous sorbefacients for female hormones or derivatives thereof; and preparations for percutaneous absorption which comprise a styrene/isoprene/styrene block copolymer and/or polyisobutylene, a softener and a tackifier as the base components, hormones, in particular, follicle hormone and/or luteal hormone as the drug component and hexylene glycol and l-menthol as a sorbefacient.
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公开(公告)号：EP1238664B1
公开(公告)日：2007-02-14
申请号：EP00981746.1
申请日：2000-12-15
发明人： TSURUDA, Kiyomi, Hisamitsu Pharmaceutical Co. Inc. , IKEURA, Yasuhiro, Hisamitsu Pharmaceutical Co. Inc
CPC分类号： A61K9/7053 , A61K9/7076 , A61K47/32
摘要： Adhesive preparations which little irritate the skin, have an excellent stability over prolonged storage and a high heat stability and show favorable adhesiveness in using. Namely, adhesive preparations comprising a styrene-isoprene-styrene block copolymer, polyisobutylenes, a takcifier, a plasticizer and a drug component, characterized in that two or more polyisobutylenes having different average molecular weights are used in combination, the viscosity of the adhesive in the adhesive preparations ranges from 1,500 to 30,000 P (60 DEG C), and the adhesive force thereof ranges from 5 to 200 g/10 mm.
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公开(公告)号：EP1238664A1
公开(公告)日：2002-09-11
申请号：EP00981746.1
申请日：2000-12-15
发明人： TSURUDA, Kiyomi, Hisamitsu Pharmaceutical Co. Inc. , IKEURA, Yasuhiro, Hisamitsu Pharmaceutical Co. Inc
CPC分类号： A61K9/7053 , A61K9/7076 , A61K47/32
摘要： This invention provides a patch with less skin stimulation, excellent in long time store stability and heat stability and having favorable tack during use. The patch comprising a styrene - isoprene - styrene block copolymer, polyisobutylene, tackifier, plasticizer and pharmaceutically effective ingredient, in which two or more kinds of polyisobutylene of different average molecular weight are used in combination and the viscosity of the adhesive of the patch is between 1500 and 30,000 poise (at 60°C) and the tack of the patch is from 5 to 200 g/10 mm.
摘要翻译： 本发明提供具有较少皮肤刺激的贴剂，在长时间储存稳定性和热稳定性方面优异，并且在使用期间具有良好的粘着性。 包含苯乙烯 - 异戊二烯 - 苯乙烯嵌段共聚物，聚异丁烯，增粘剂，增塑剂和药学上有效成分的贴剂，其中组合使用两种或更多种不同平均分子量的聚异丁烯，并且贴剂的粘合剂的粘度在 1500和30,000泊（60℃），贴片的粘性为5〜200g / 10mm。
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4.发明公开SORBEFACIENTS AND PREPARATIONS FOR PERCUTANEOUS ABSORPTION CONTAINING THE SAME 有权吸收剂BESCHLEUNIGER UND DIEE ENTHALTENDE ZUBEREITUNGEN ZUR TRANSDERMALEN吸收
公开(公告)号：EP1121941A1
公开(公告)日：2001-08-08
申请号：EP99947897.7
申请日：1999-10-14
发明人： IKEURA, Yasuhiro, Hisamitsu Pharmaceutical Co. Inc , MAKI, Masayoshi, Hisamitsu Pharmaceutical Co. Inc.
IPC分类号： A61K47/10 , A61K47/32 , A61K31/565 , A61K31/57
CPC分类号： A61K9/7053 , A61K9/0014 , A61K9/7076 , A61K31/565 , A61K31/57 , A61K47/10
摘要： Percutaneous sorbefacients comprising hexylene glycol and 1-menthol, more particularly, percutaneous sorbefacients for female hormones or derivatives thereof; and preparations for percutaneous absorption which comprise a styrene/isoprene/styrene block copolymer and/or polyisobutylene, a softener and a tackifier as the base components, hormones, in particular, follicle hormone and/or luteal hormone as the drug component and hexylene glycol and 1-menthol as a sorbefacient.
摘要翻译： 包含己二醇和1-薄荷醇的经皮吸收剂，更具体地，涉及雌激素或其衍生物的经皮吸收剂; 以及包含苯乙烯/异戊二烯/苯乙烯嵌段共聚物和/或聚异丁烯，软化剂和增粘剂作为基础组分的激素，特别是作为药物组分和己二醇的激素和/或黄体激素的经皮吸收制剂，以及 1-薄荷醇作为吸收剂。
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