公开(公告)号：EP1217007A2

公开(公告)日：2002-06-26

申请号：EP02000397.6

申请日：1995-06-28

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Hudson, Peter L. ,  He, Wei fu ,  Ruben, Steven M.

IPC分类号： C07K16/40 ,  G01N33/573

CPC分类号： C12N9/16 ,  A61K38/00 ,  A61K48/00 ,  C12N9/18 ,  Y10S530/809

摘要： Human serum paraoxonase enzyme and DNA (RNA) encoding such serum paraoxonase enzymes are disclosed. Also provided is the procedure for producing such polypeptides by recombinant techniques. Uses of such polypeptides include their use as an antidote for organophosphate poisoning and to prevent neuronal cell death. Diagnostic assays for identifying mutations in a nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

摘要翻译： 公开了人血清对氧磷酶和编码这种血清对氧磷酶的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 这些多肽的用途包括其用作有机磷中毒的解毒剂并防止神经元细胞死亡的用途。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并检测本发明多肽的改变水平的诊断测定。