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公开(公告)号：EP1712631A2
公开(公告)日：2006-10-18
申请号：EP06010773.7
申请日：1998-01-20
发明人： Olsen, Henrik , Ni, Jian , Murphy, Marianne , Ruben, Steven , Gentz, Reiner
CPC分类号： C07K14/70535
摘要： The present invention relates to five novel Fc receptor-like proteins which are members of the Fc Receptor family. In particular, isolated nucleic acid molecules are provided encoding the human FcR-I, FcR-II, FcR-III, FcR-IV and FcR-V proteins. FcR-I, FcR-II, FcR-III, FcR-IV and FcR-V polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of FcR-I, FcR-II, FcR-III, FcR-IV and FcR-V activities. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译： 本发明涉及作为Fc受体家族成员的五种新的Fc受体样蛋白。 特别地，提供编码人FcR-1，FcR-II，FcR-III，FcR-IV和FcR-V蛋白的分离的核酸分子。 还提供FcR-1，FcR-II，FcR-III，FcR-IV和FcR-V多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定FcR-1，FcR-II，FcR-III，FcR-IV和FcR-V活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。
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公开(公告)号：EP1712631A3
公开(公告)日：2009-01-21
申请号：EP06010773.7
申请日：1998-01-20
发明人： Olsen, Henrik , Ni, Jian , Murphy, Marianne , Ruben, Steven , Gentz, Reiner
CPC分类号： C07K14/70535
摘要： The present invention relates to five novel Fc receptor-like proteins which are members of the Fc Receptor family. In particular, isolated nucleic acid molecules are provided encoding the human FcR-I, FcR-II, FcR-III, FcR-IV and FcR-V proteins. FcR-I, FcR-II, FcR-III, FcR-IV and FcR-V polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of FcR-I, FcR-II, FcR-III, FcR-IV and FcR-V activities. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
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