公开(公告)号：EP0752844A1

公开(公告)日：1997-01-15

申请号：EP94914946.0

申请日：1994-04-29

申请人： HUMAN GENOME SCIENCES, INC. ,  SMITHKLINE BEECHAM CORPORATION

发明人： HASTINGS, Gregg A. ,  ADAMS, Mark D. ,  FRASER, Claire M. ,  LEE, Norman H. ,  KIRKNESS, Ewen F. ,  BLAKE, Judith A. ,  FITZGERALD, Lisa M. ,  DRAKE, Fred H. ,  GOWAN, Maxine

IPC分类号： G01N33 ,  A61K31 ,  A61K38 ,  A61K39 ,  A61K48 ,  A61P19 ,  A61P35 ,  A61P43 ,  C07H21 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12N9 ,  C12N15 ,  C12P19 ,  C12P21 ,  C12Q1

CPC分类号： C12N9/6472 ,  A61K38/00 ,  C07K16/40

摘要： Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA (RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.