公开(公告)号：EP0816829A2

公开(公告)日：1998-01-07

申请号：EP97108773.9

申请日：1997-06-02

申请人： HUTCHINSON TECHNOLOGY, INC.

发明人： Anderson, David L. ,  Houk, Galen D. ,  Lewandowski, Mark S. ,  Myers, Dean E. ,  Ortner, Joseph P.

IPC分类号： G01N21/31

CPC分类号： G01J3/433 ,  A61B5/14551 ,  A61B5/14553 ,  A61B5/1495 ,  A61B5/7264 ,  A61B2562/0242 ,  G01N21/314

摘要： A method and apparatus for determining concentrations of a predetermined tissue chromophore with respect to the total concentration of a different, but related tissue chromophore within a predetermined tissue of interest which may, but need not have physiological characteristics observed in blood-containing tissue. The aforesaid is achieved by first measuring an absorbance spectrum for the tissue at a multiplicity of predetermined wavelengths. The absorbance spectrum is transformed into a second derivative spectrum which is subsequently scaled, rendering a spectrum which is robust to changes in amplitude and constant slope bias as well as to changes in optical pathlength and total chromophore concentration. Selected spectra obtained from the scaled second derivative spectrum is manipulated within a neural network to generate quantified output data values representative of actual concentrations of the predetermined tissue chromophore with respect to the total concentration of the different, but related chromophore.

摘要翻译： 一种用于确定预定组织发色团的浓度的方法和装置，其相对于感兴趣的预定组织内的不同但相关的组织发色团的总浓度，其可能但不必具有在含血液组织中观察到的生理特征。 上述是通过首先以多种预定波长测量组织的吸收光谱来实现的。 吸收光谱被转换成随后缩放的二阶导数光谱，使得对振幅和恒定斜率偏差变化以及光程长度和总发色团浓度变化是鲁棒的光谱。 从缩放的二阶导数光谱获得的选定光谱在神经网络内被操纵以产生代表预定组织发色团的实际浓度的量化输出数据值，相对于不同但相关的发色团的总浓度。

公开(公告)号：EP0816829B1

公开(公告)日：2003-08-27

申请号：EP97108773.9

申请日：1997-06-02

申请人： HUTCHINSON TECHNOLOGY, INC.

发明人： Anderson, David L. ,  Houk, Galen D. ,  Lewandowski, Mark S. ,  Myers, Dean E. ,  Ortner, Joseph P.

IPC分类号： G01N21/31

CPC分类号： G01J3/433 ,  A61B5/14551 ,  A61B5/14553 ,  A61B5/1495 ,  A61B5/7264 ,  A61B2562/0242 ,  G01N21/314

公开(公告)号：EP0816829A3

公开(公告)日：1998-04-29

申请号：EP97108773.9

申请日：1997-06-02

申请人： HUTCHINSON TECHNOLOGY, INC.

发明人： Anderson, David L. ,  Houk, Galen D. ,  Lewandowski, Mark S. ,  Myers, Dean E. ,  Ortner, Joseph P.

IPC分类号： G01N21/31

CPC分类号： G01J3/433 ,  A61B5/14551 ,  A61B5/14553 ,  A61B5/1495 ,  A61B5/7264 ,  A61B2562/0242 ,  G01N21/314

摘要： A method and apparatus for determining concentrations of a predetermined tissue chromophore with respect to the total concentration of a different, but related tissue chromophore within a predetermined tissue of interest which may, but need not have physiological characteristics observed in blood-containing tissue. The aforesaid is achieved by first measuring an absorbance spectrum for the tissue at a multiplicity of predetermined wavelengths. The absorbance spectrum is transformed into a second derivative spectrum which is subsequently scaled, rendering a spectrum which is robust to changes in amplitude and constant slope bias as well as to changes in optical pathlength and total chromophore concentration. Selected spectra obtained from the scaled second derivative spectrum is manipulated within a neural network to generate quantified output data values representative of actual concentrations of the predetermined tissue chromophore with respect to the total concentration of the different, but related chromophore.