公开(公告)号：EP2167492A2

公开(公告)日：2010-03-31

申请号：EP08766124.5

申请日：2008-06-05

申请人： Hanmi Pharm. Co., Ltd.

发明人： LEE, Kwang-Ok ,  CHA, Mi Young ,  KIM, Mi Ra ,  JUNG, Young Hee ,  LEE, Chang Gon ,  KIM, Se Young ,  BANG, Keukchan ,  PARK, Bum Woo ,  CHOI, Bo Im ,  CHAE, Yun Jung ,  KO, Mi Young ,  KIM, Han Kyong ,  AHN, Young-Gil ,  KIM, Maeng Sup ,  LEE, Gwan Sun

IPC分类号： C07D403/12

CPC分类号： C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14

摘要： The present invention provides a novel amide derivative and a pharmaceutically acceptable salt thereof which selectively and effectively inhibits the growth of cancer cells induced by the overexpression of an epidermal growth factor receptor and also prevents the development of drug resistance caused by the mutation of EGFR tyrosine kinase, and a pharmaceutical composition comprising same as an active ingredient.