-
公开(公告)号：EP2763981B1
公开(公告)日：2020-01-08
申请号：EP12838558.0
申请日：2012-10-05
IPC分类号： C07D401/12 , A61K31/517 , C07D239/94
-
2.发明公开METHOD FOR PREPARING TETRAZOLE METHANESULFONIC ACID SALTS, AND NOVEL COMPOUND USED IN SAME 有权用于生产四唑甲烷硫酸盐及采用了新的CONNECTION
公开(公告)号：EP2524916A2
公开(公告)日：2012-11-21
申请号：EP11733103.3
申请日：2011-01-14
发明人： BANG, Keuk Chan , PARK, Bum Woo , CHOI, Jong Won , LEE, Jae Chul , AN, Yong Hoon , AHN, Young Gil , KIM, Maeng Sup
IPC分类号： C07D405/14 , C07D403/02 , C07D417/12
CPC分类号： C07D417/12 , C07D403/10 , C07D405/12 , C07D405/14
摘要： According to the present invention, a method for preparing tetrazole methanesulfonic acid salts comprises an acylation reaction using a novel 4-iodine-4H-chromene-2-carbothionic acid S-benzothiazole-2-yl ester. The method of the present invention can shorten a reaction time and improve safety as compared to conventional methods, and can prepare high-purity tetrazole methanesulfonic acid salts at a high yield rate without using a column chromatography method.
摘要翻译： 。根据本发明，用于使用新的4-碘-4H-苯并吡喃-2- carbothionic酸S-苯并噻唑-2-基酯制备四唑甲磺酸盐酰化反应包括一种方法。 本发明的方法可以缩短反应时间，提高安全性与传统方法相比，能够以高收率制备率的高纯度四唑甲磺酸盐，而无需使用柱色谱法。
-
3.发明公开
公开(公告)号：EP3611172A1
公开(公告)日：2020-02-19
申请号：EP19201644.2
申请日：2012-10-05
IPC分类号： C07D401/12 , A61K31/517
摘要： The present invention relates to an improved method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-one, which selectively and effectively inhibits the growth of cancer cells induced by over-expression of an epidermal growth factor receptor (EGFR) and prevents the development of drug resistance caused by mutation of a tyrosine kinase.
-
4.发明公开METHOD FOR PREPARING 1-(4-(4-(3,4-DICHLORO-2-FLUOROPHENYLAMINO)-7-METHOXYQUINAZOLIN-6-YLOXY)PIPERIDIN-1-YL)-PROP-2-EN-1-ONE HYDROCHLORIDE AND INTERMEDIATES USED THEREIN 审中-公开PROCESS FOR 1-（4-（4-（3,4-二氯-2-氟 - 苯基氨基）-7-甲氧基-6-基氧基） - 哌啶-1-基） - 丙-2-烯-1-酮盐酸盐的制备 而用于中间产品
公开(公告)号：EP2763981A2
公开(公告)日：2014-08-13
申请号：EP12838558.0
申请日：2012-10-05
IPC分类号： C07D401/12 , A61K31/517
摘要： The present invention relates to an improved method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-one hydrochloride, which selectively and effectively inhibits the growth of cancer cells induced by over-expression of an epidermal growth factor receptor (EGFR) and prevents the development of drug resistance caused by mutation of a tyrosine kinase, and intermediates used therein.
-
5.发明授权METHOD FOR PREPARING TETRAZOLE METHANESULFONIC ACID SALTS, AND NOVEL COMPOUND USED IN SAME 有权用于生产四唑甲烷硫酸盐及采用了新的连接
公开(公告)号：EP2524916B1
公开(公告)日：2014-07-23
申请号：EP11733103.3
申请日：2011-01-14
发明人： BANG, Keuk Chan , PARK, Bum Woo , CHOI, Jong Won , LEE, Jae Chul , AN, Yong Hoon , AHN, Young Gil , KIM, Maeng Sup
IPC分类号： C07D405/14 , C07D403/02 , C07D417/12 , C07D403/10 , C07D405/12
CPC分类号： C07D417/12 , C07D403/10 , C07D405/12 , C07D405/14
-
-
-
-
搜索结果
5 条记录 (耗时 0.01 秒)
