公开(公告)号：EP4006010A1

公开(公告)日：2022-06-01

申请号：EP20847360.3

申请日：2020-06-05

申请人： Hebei Lansheng Biotech Co., Ltd ,  Hebei Lanrun Plant Protection Technology Co., Ltd. ,  Hebei Guzhirun Technology Co., Ltd

发明人： GUO, Qingchun ,  DONG, Zhipeng ,  YUAN, Ligang ,  LIU, Hailong ,  GUO, Hongyong

IPC分类号： C07C253/34

摘要： Disclosed is an improved method for preparing a maleate salt of cis-para-substituted cyclohexylamino nitrile depicted by formula (I), the method comprising adding maleic acid, at a molar ratio of 0.3 to 0.55, to a solution of para-substituted cis- and trans-cyclohexylamino nitrile compounds corresponding to formula (I) in an organic solvent, performing stirring and ultrasonic treatment, and then performing further processes such as filtering to obtain the maleate salt of cis-para-substituted cyclohexylamino nitrile depicted by formula (I), where R 1 is a C 1 -C 10 alkyl or alkyloxy group, a C 1 -C 10 alkenyl or alkenyloxy group, a C 1 -C 10 alkynyl or alkynyloxy group, a C 1 -C 10 cycloalkyl or cycloalkyloxy group, or a C 1 -C 10 heterocycloalkyl or heterocycloalkyloxy group containing 1-2 heteroatoms selected from O and N, and HX is maleic acid.

公开(公告)号：EP3819289A1

公开(公告)日：2021-05-12

申请号：EP19815317.3

申请日：2019-07-20

申请人： Hebei Lansheng Biotech Co., Ltd ,  Cangzhou Lingangxingye Chemtech Co., Ltd

发明人： DONG, Zhipeng ,  GUO, Qingchun ,  LIN, Bin ,  YUAN, Ligang ,  GUO, Hongyong ,  ZHANG, Zhihu ,  XU, Feng ,  WANG, Shihua ,  SONG, Haiwen ,  LIU, Hailong ,  LI, Longqiang ,  CUI, Debao ,  ZHANG, Song ,  ZHAO, Xiaodong ,  WU, Zhichao ,  WANG, Xuhao

IPC分类号： C07C253/32 ,  C07C255/46 ,  C07C233/52 ,  C07C231/12

摘要： Provided are a cis-para-substituted cyclohexylamino nitrile salt as shown in formula (I) and a preparation method therefor, a use of said salt as a preparation intermediate to prepare a pesticide such as spirotetramat. In formula (I), the para-substituent R is C 1-10 alkyl or alkyloxy, C 1-10 alkenyl or alkenyloxy, C 1-10 alkynyl or alkynyloxy, C 1-10 cycloalkyl or cycloalkyloxy, C 1-10 heterocycloalkyl or heterocycloalkyloxy containing 1-2 heteroatoms selected from O and N, and HX is hydroxyacetic acid or maleic acid.