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1.发明公开TRISPECIFIC BINDING MOLECULES FOR TREATING HBV INFECTION AND ASSOCIATED CONDITIONS 审中-公开用于治疗HBV感染的三特异性结合分子及相关病症
公开(公告)号：EP3271387A1
公开(公告)日：2018-01-24
申请号：EP16711223.4
申请日：2016-03-16
申请人： Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) , Deutsches Krebsforschungszentrum , Technische Universität München
CPC分类号： C07K16/082 , A61K2039/505 , A61K2039/507 , C07K16/2803 , C07K16/2809 , C07K16/2818 , C07K16/283 , C07K16/2851 , C07K16/2878 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/50 , C07K2317/60 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2319/00
摘要： The present invention relates to a binding molecule comprising at least three binding specificities, wherein (a) the first specificity is for a Hepatitis B virus (HBV) surface antigen selected from HBV small surface antigen, HBV medium surface antigen and HBV large surface antigen; (b) (i) the second and third specificity are for CD3 and CD28, respectively; or (ii) the second and third specificity are selected from specificities for CD16, CD56, NKp30, NKp46, 4-1BB and NKG2D; and (c) each binding specificity is provided by one or more binding sites, each binding site being independently provided by (i) a set of six complementarity determining regions (CDRs), wherein said set of six CDRs consists of a first set of three CDRs and a second set of three CDRs, wherein said first and said second set is each comprised in an immunoglobulin domain; or (ii) a set of three CDRs, wherein said set of three CDRs is comprised in an immunoglobulin domain.
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2.发明公开BI- OR MULTISPECIFIC POLYPEPTIDES BINDING IMMUNE EFFECTOR CELL SURFACE ANTIGENS AND HBV ANTIGENS FOR TREATING HBV INFECTIONS AND ASSOCIATED CONDITIONS 审中-公开BI或多特异性多肽免疫效应细胞表面抗原和HBV抗原用于治疗HBV感染和相关疾病约束力
公开(公告)号：EP3046938A1
公开(公告)日：2016-07-27
申请号：EP14771250.9
申请日：2014-09-16
申请人： Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) , Deutsches Krebsforschungszentrum
IPC分类号： C07K16/08 , C07K16/28 , C07K16/46 , A61K39/395 , A61P31/20
CPC分类号： C07K16/2809 , A61K2039/505 , A61K2039/507 , C07K16/082 , C07K16/2803 , C07K16/2818 , C07K16/283 , C07K2317/14 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2319/00 , C12N5/0638 , C12N5/0646
摘要： The present invention relates to a polypeptide comprising (a) a first set of six complementarity determining regions (CDRs) configured to bind a first antigen; and (b) (ba) a second set of six CDRs configured to bind a second antigen; or (bb) a ligand capable of binding to a second antigen; wherein (i) said first antigen is selected from Hepatitis B virus (HBV) small surface antigen; HBV medium surface antigen; and HBV large surface antigen; and (ii) said second antigen is selected from surface antigens presented by immune effector cells such as natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). Also provided are compositions for use in a method of treating or preventing HBV infection and/or a condition caused by said HBV infection, said condition caused by said HBV infection being selected from liver cirrhosis and hepatocellular carcinoma.
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