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1.发明授权UTILISATION D'UNE GLOBINE, D'UN PROTOMERE DE GLOBINE OU D'UNE HEMOGLOBINE EXTRACELLULAIRE POUR LA PRESERVATION D'ORGANES, DE TISSUS, OU DE CELLULES D'ORGANES OU DE TISSUS 有权利用德国诺贝尔生物技术公司德国诺贝尔生物技术公司德国奥尔良生物技术公司德国奥尔良生物技术公司
公开(公告)号：EP2184977B1
公开(公告)日：2017-07-12
申请号：EP08840369.6
申请日：2008-07-25
申请人： Hemarina SA , Centre National de la Recherche Scientifique , Université Pierre et Marie Curie (Paris 6)
IPC分类号： A01N1/02
CPC分类号： A61K38/42 , A01N1/02 , A01N1/0226 , C12N5/0037
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2.发明公开
公开(公告)号：EP2164532A2
公开(公告)日：2010-03-24
申请号：EP08826127.6
申请日：2008-06-10
发明人： ZAL, Franck , ROUSSELOT, Morgane
CPC分类号： A61L26/0023 , A61K8/64 , A61K8/73 , A61K8/731 , A61K8/733 , A61K8/736 , A61K38/42 , A61L15/28 , A61L15/44 , A61L26/0066 , A61L26/008 , A61L26/0085 , A61L26/0095 , A61L2300/252 , A61L2300/412 , A61Q19/00
摘要： The invention relates to the use of a haemoglobin for the preparation of dressings and to the resulting dressings.
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3.发明授权
公开(公告)号：EP2164532B1
公开(公告)日：2012-02-01
申请号：EP08826127.6
申请日：2008-06-10
发明人： ZAL, Franck , ROUSSELOT, Morgane
CPC分类号： A61L26/0023 , A61K8/64 , A61K8/73 , A61K8/731 , A61K8/733 , A61K8/736 , A61K38/42 , A61L15/28 , A61L15/44 , A61L26/0066 , A61L26/008 , A61L26/0085 , A61L26/0095 , A61L2300/252 , A61L2300/412 , A61Q19/00
摘要： The invention relates to the use of a haemoglobin for the preparation of dressings and to the resulting dressings.
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4.发明公开
公开(公告)号：EP2184977A2
公开(公告)日：2010-05-19
申请号：EP08840369.6
申请日：2008-07-25
申请人： Hemarina SA , Centre National de la Recherche Scientifique , Universite Pierre Et Marie Curie - Paris 6
IPC分类号： A01N1/02
CPC分类号： A61K38/42 , A01N1/02 , A01N1/0226 , C12N5/0037
摘要： The invention relates to the use of at least one globin and/or at least one globin protomer and/or at least one naturally extracellular native hemoglobin for the preservation of organs, tissues, organ and tissue cells and cell cultures.
摘要翻译： 球蛋白和/或珠蛋白原体和/或天然血红蛋白，自然细胞外，无脊椎动物门环节动物，包括使用，属于海洋蠕虫包括沙柳码头，在0625至100毫克/毫升，优选为1.25毫克/毫升的浓度 在与器官防腐液，或细胞培养基，用于构成对器官，组织或器官或组织保存的细胞的组合物，用于器官或组织的灌注组合，或器官的细胞或组织的培养物，其特征在于。 独立权利要求中包括了：（1）组合物，包含珠蛋白和/或珠蛋白原体和/或细胞外血红蛋白和器官保存液; （2）用于保存的器官或组织或器官或组织，优选器官的细胞，其包括漂洗以前收集的器官或组织中，在4-37 [℃，优选4℃，的温度下与过程 该组合物，并在4-37℃下]℃的温度下通过静态或动态灌注的器官或组织的防腐剂，优选为4 [℃，对于一个确定的开采时间，雅丁到器官或组织中，在组合物中; （3），用于从脊椎动物的器官培养器官的细胞或组织的细胞，包括培养的细胞，从脊椎动物采集以前，在4-37℃下]℃的温度下，优选37℃，对于一流程 规定期间，根据在组合物中的细胞，并收集由洗涤和细胞垫的裂解所述细胞; 和（4）中培养来自脊椎动物脏器的细胞或组织的细胞，包括收集无脊椎动物的细胞中，在4-37℃下]℃的温度下培养的方法，优选为4 [℃，对于一个固定的时间，这取决于 在组合物中的细胞，并收集由所述细胞垫的洗涤和裂解细胞。
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5.发明公开
公开(公告)号：EP1673155A2
公开(公告)日：2006-06-28
申请号：EP04817226.6
申请日：2004-10-13
IPC分类号： B01D1/00
CPC分类号： C07K14/805
摘要： The invention relates to a method of dissociating the extracellular haemoglobin molecule of annelids, e.g. Arenicola marina, which can be used to obtain the protein chains forming said molecule. The inventive method is characterised in that it comprises a step consisting in bringing an extracellular haemoglobin sample from annelids, e.g. Arenicola marina, into contact with at least one dissociating agent, e.g. a mixture containing dithiothreitol (DTT) or tris(2-carboxyethyl)phosphine (TCEP) hydrochloride or beta-mercaptoethanol and a dissociation buffer for a sufficient length of time in order to separate the protein chains from one another.
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6.发明授权
公开(公告)号：EP1976865B1
公开(公告)日：2012-11-14
申请号：EP07704085.5
申请日：2007-01-23
发明人： ZAL, Franck , ROUSSELOT, Morgane
IPC分类号： C07K14/805 , C07K14/41 , C07K14/435 , A61K38/42
CPC分类号： C07K14/805 , A61K38/42
摘要： The present invention relates to the use of a high molecular weight extracellular hemoglobin for the manufacture of a medicament for treating and/or preventing diseases by inhibition of calcium. Advantageously, the extracellular hemoglobin is obtained from Annelids. In particular, the invention concerns the use of a high molecular weight extracellular hemoglobin for the manufacture of a medicament for treating and/or preventing cardiovascular diseases, such as hypertension, angina such as angina pectoris, Raynaud's disease, arteriopathy, tachycardia, vasospasm, ischemia, myocardial infarction, congestive heart failure, arrhythmia or cerebrovacular accident.
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7.发明授权
公开(公告)号：EP1673155B1
公开(公告)日：2012-08-22
申请号：EP04817226.6
申请日：2004-10-13
IPC分类号： B01D1/00
CPC分类号： C07K14/805
摘要： The invention relates to a method of dissociating the extracellular haemoglobin molecule of annelids, e.g. Arenicola marina, which can be used to obtain the protein chains forming said molecule. The inventive method is characterised in that it comprises a step consisting in bringing an extracellular haemoglobin sample from annelids, e.g. Arenicola marina, into contact with at least one dissociating agent, e.g. a mixture containing dithiothreitol (DTT) or tris(2-carboxyethyl)phosphine (TCEP) hydrochloride or beta-mercaptoethanol and a dissociation buffer for a sufficient length of time in order to separate the protein chains from one another.
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8.发明公开
公开(公告)号：EP1976865A1
公开(公告)日：2008-10-08
申请号：EP07704085.5
申请日：2007-01-23
发明人： ZAL, Franck , ROUSSELOT, Morgane
IPC分类号： C07K14/00
CPC分类号： C07K14/805 , A61K38/42
摘要： The present invention relates to the use of a high molecular weight extracellular hemoglobin for the manufacture of a medicament for treating and/or preventing diseases by inhibition of calcium. Advantageously, the extracellular hemoglobin is obtained from Annelids. In particular, the invention concerns the use of a high molecular weight extracellular hemoglobin for the manufacture of a medicament for treating and/or preventing cardiovascular diseases, such as hypertension, angina such as angina pectoris, Raynaud's disease, arteriopathy, tachycardia, vasospasm, ischemia, myocardial infarction, congestive heart failure, arrhythmia or cerebrovacular accident.
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