专利检索 ap:("Hematech, LLC" OR "KIRIN BREWERY COMPANY LTD.") AND inv:"ISHIDA, Isao352-6 Kushihashi" 第 1 页

1.

发明公开
TRANSGENIC UNGULATES HAVING REDUCED PRION PROTEIN ACTIVITY AND USES THEREOF 审中-公开
标题翻译：具有降低朊蛋白的转基因活性的有蹄类动物及其用途

公开(公告)号：EP1563084A2

公开(公告)日：2005-08-17

申请号：EP03783271.4

申请日：2003-11-10

申请人： Hematech, LLC , KIRIN BREWERY COMPANY LTD.

发明人： ROBL, James , KUROIWA, Yoshimi , COLLAS, Philippe , SULLIVAN, Eddie , KASINATHAN, Poothappillai , TOMIZUKA, Kazuma401, RM2 Takasaki , ISHIDA, Isao352-6 Kushihashi

IPC分类号： C12P21/00 , A01K67/027 , C12N15/00 , C12N5/02 , C12N5/06 , C12N5/16

CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2227/101 , A01K2267/01 , A01K2267/02 , C07K16/00 , C07K2317/12 , C07K2317/21 , C12N2800/30

摘要： The invention provides cloned transgenic ungulates (e.g., bovines) in which prion protein activity is reduced by one or more genetically engineered mutations. Desirably, these transgenic bovines are also genetically modified to express xenogenous (e.g., human) antibodies. Because of their resistance to prion-related diseases such as bovine spongiform encephalopy (also known as mad cow disease), these bovines are a safer source of human antibodies for pharmaceutical uses and safer source of agricultural products.