专利检索 ap:("Henan Genuine Biotech Co., Ltd.") AND inv:"LI, Jianyong" 第 1 页

1.

发明公开
2-(2,4,5-SUBSTITUTED PHENYLAMINO)PYRIMIDINE DERIVATIVE AND CRYSTAL FORM B THEREOF 审中-公开

公开(公告)号：EP3954682A1

公开(公告)日：2022-02-16

申请号：EP19924592.9

申请日：2019-04-09

申请人： Henan Genuine Biotech Co., Ltd.

发明人： CHANG, Junbiao , DU, Jinfa , ZHU, Kaikai , WANG, Kai , LI, Jianyong , ZHANG, Chunxia , YI, Dongxu

IPC分类号： C07D403/04 , A61P35/00

摘要： The present invention discloses a new anti-lung cancer medicine, and specifically relates to a 2-(2,4,5-substituted phenylamino)pyrimidine derivative I and a crystal form B thereof, belonging to the field of medicinal chemistry. The derivative has the following structure: (1). According to the results of pharmacokinetic and pharmacodynamic research, doxitinib significantly reduces the production of a metabolic product N-Me with a greater toxicity, and maintains or improves the efficacy in comparison to osimertinib. Doxitinib is expected to be developed as a safer and more effective novel medicine for the treatment of non-small cell lung cancer with EGFR mutation in comparison to osimertinib.