专利检索 ap:("Hetero Drugs Limited") AND inv:"MURALIDHARA REDDY, D., Hetero Drugs Limited R & D" 第 1 页

1.

发明授权
A NOVEL PROCESS FOR PREPARATION OF CEFPROZIL INTERMEDIATE 有权
标题翻译：生产头孢丙烯，中间体的新方法

公开(公告)号：EP1809638B1

公开(公告)日：2010-02-17

申请号：EP04806740.9

申请日：2004-11-01

申请人： Hetero Drugs Limited

发明人： PARTHASARADHI REDDY, Bandi , RATHNAKAR REDDY, K., Hetero Drugs Limited (R & D) , RAJI REDDY, R., Hetero Drugs Limited (R & D) , MURALIDHARA REDDY, D., Hetero Drugs Limited R & D , MURALI, Nagabelli, Hetero Drugs Limited

IPC分类号： C07D501/04 , C07D501/22

CPC分类号： C07D501/22 , C07F7/188

摘要： The present invention relates to a process for preparing a key intermediate of cefprozil and use of this intermediate in the preparation of cefprozil thereby avoiding impurity-causing self-acylation. [R-(Z)]-[4-hydroxy-α-[(3-methoxy-l-methyl-3-oxo-1-propenyl)amino]] benzeneacetic acid, mono potassium salt is reacted with ethyl chloroformate to obtain mixed anhydride which is then silylated with N,O-bis(trimethylsilyl)acetamide. The silylated compound obtained is reacted with [7-trimethylsilylamino-3-(Z/E-propen-1-yl)-3-cephem-4-carboxylic acid]trimethylsilyl ester and deprotected with aqueous hydrochloric acid to give cefprozil.

2.

发明公开
A NOVEL PROCESS FOR PREPARATION OF CEFPROZIL INTERMEDIATE 有权
标题翻译：生产头孢丙烯，中间体的新方法

公开(公告)号：EP1809638A1

公开(公告)日：2007-07-25

申请号：EP04806740.9

申请日：2004-11-01

申请人： Hetero Drugs Limited

发明人： PARTHASARADHI REDDY, Bandi , RATHNAKAR REDDY, K., Hetero Drugs Limited (R & D) , RAJI REDDY, R., Hetero Drugs Limited (R & D) , MURALIDHARA REDDY, D., Hetero Drugs Limited R & D , MURALI, Nagabelli, Hetero Drugs Limited

IPC分类号： C07D501/04 , C07D501/22

CPC分类号： C07D501/22 , C07F7/188

摘要： The present invention relates to a process for preparing a key intermediate of cefprozil and use of this intermediate in the preparation of cefprozil thereby avoiding impurity-causing self-acylation. [R-(Z)]-[4-hydroxy-α-[(3-methoxy-l-methyl-3-oxo-1-propenyl)amino]] benzeneacetic acid, mono potassium salt is reacted with ethyl chloroformate to obtain mixed anhydride which is then silylated with N,O-bis(trimethylsilyl)acetamide. The silylated compound obtained is reacted with [7-trimethylsilylamino-3-(Z/E-propen-1-yl)-3-cephem-4-carboxylic acid]trimethylsilyl ester and deprotected with aqueous hydrochloric acid to give cefprozil.