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1.发明公开Sydnonimine derivatives, process for production thereof, and use thereof 失效Sydnonimin-Derivate，Verfahren zu deren Herstellung und deren Verwendung。
公开(公告)号：EP0073345A2
公开(公告)日：1983-03-09
申请号：EP82106796.4
申请日：1982-07-27
申请人： Hidaka, Hiroyoshi
IPC分类号： C07D271/04 , A61K31/495
CPC分类号： C07D295/28 , C07D271/04 , Y10S514/929
摘要： A 3-[4-benzoylalkyl)piperazin-1-yl]sydnonimine compound represented by the following formula
wherein R represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, and n represents zero or an integer of 1 to 10,
and its acid addition salt. The above sydnonimine compounds are useful for the treatment of troubles of the circulatory system and can be produced by contacting a 4-(benzoylalkyl)-1-(N-nitrosocyanomethylamino)piperazine represented by the following formula
I wherein R and n are as defined, with an acid.摘要翻译： 由下式表示的3- [4-苯甲酰基烷基]哌嗪-1-基]次氨基亚胺化合物...
其中R表示氢原子或具有1至8个碳原子的烷基，n表示0或整数 为1〜10，...及其酸加成盐。 上述的sydnonimine化合物可用于治疗循环系统的麻烦，并且可以通过使由下式表示的4-（苯甲酰基烷基）-1-（N-亚硝基氰基甲基氨基）哌嗪与 与酸定义一致。 -
2.发明公开Sydnonimine derivatives, process for production thereof, and use thereof 失效SYDNONIMINE衍生物，其生产方法及其用途
公开(公告)号：EP0073345A3
公开(公告)日：1984-03-21
申请号：EP82106796
申请日：1982-07-27
申请人： Hidaka, Hiroyoshi
IPC分类号： C07D271/04 , A61K31/495
CPC分类号： C07D295/28 , C07D271/04 , Y10S514/929
摘要： A 3-[4-benzoylalkyl)piperazin-1-yl]sydnonimine compound represented by the following formula
wherein R represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, and n represents zero or an integer of 1 to 10,
and its acid addition salt. The above sydnonimine compounds are useful for the treatment of troubles of the circulatory system and can be produced by contacting a 4-(benzoylalkyl)-1-(N-nitrosocyanomethylamino)piperazine represented by the following formula
I wherein R and n are as defined, with an acid.-
3.发明公开N-acyl-3-(4-(benzoylalkyl)piperazin-1-yl)-sydnonimine compound, process for production thereof, and use thereof 失效N-酰基 - 3-（4-（的苯甲酰基）哌嗪-1-基）-sydnonimine衍生物，它们的制备方法和它们的用途。
公开(公告)号：EP0076952A1
公开(公告)日：1983-04-20
申请号：EP82108846.5
申请日：1982-09-24
申请人： Hidaka, Hiroyoshi
IPC分类号： C07D271/04 , A61K31/495
CPC分类号： C07D295/28 , C07D271/04 , Y10S514/929
摘要： An N-acyl-3-[4-(benzoylalkyl)piperazin-1-yl]-sydnonimine compound represented by the following formula
wherein R' represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, R 2 represents a lower alkyl group, a lower alkoxy group or a phenyl group, and n represents zero or an integer of 1 to 10, and its acid addition salt. The above sydnonimine compounds are useful for the treatment of troubles of the circulatory system and can be produced by contacting a 3-[4-(benzoylalkyl)-piperazin-1-yl]sydnonimine compound represented by the following for- mule
wherein R' and n are as defined, with a carboxylic acid represented by the following formula
wherein R 2 is as defined.
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