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    Novel compounds exhibiting a vasodilating activity and inhibitory activity for platelet aggregation and pharmaceutical compositions containing them
    1.
    发明公开
    Novel compounds exhibiting a vasodilating activity and inhibitory activity for platelet aggregation and pharmaceutical compositions containing them 失效
    具有血管舒张作用和抑制血小板聚集的效果和含有它们的药物组合物的化合物。

    公开(公告)号：EP0416820A2

    公开(公告)日：1991-03-13

    申请号：EP90309530.5

    申请日：1990-08-31

    申请人： Hidaka, Hiroyoshi ,  TOBISHI YAKUHIN KOGYO KABUSHIKI KAISHA

    发明人： Hidaka, Hiroyoshi ,  Ishikawa, Tomohiko ,  Inoue, Tsutomu ,  Yuasa, Masayuki ,  Inaba, Takashi ,  Naito, Kenji ,  Sakuma, Osamu ,  Morita, Tadashi ,  Kidokoro, Shinpei

    IPC分类号： C07D495/04 ,  C07D495/14 ,  A61K31/435

    CPC分类号： C07D495/04 ,  C07D495/14

    摘要： Novel compounds represented by the formula:
    wherein R₁ represents an alkyl group having 1 to 3 carbon atoms, R₂ represents an amino group or a group of formula
    in which R₄ represents an alkyl group having 1 to 3 carbon atoms, R₅ represents an alkyl group having 1 to 3 carbon atoms or may combine with R₆ to form a five or six membered ring containing 4 to 5 carbon atoms, R₆ represents a hydrogen atom or may combine with R₅ to form a five or six membered ring containing 4 to 5 carbon atoms, R₃ represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms or a halogen atom, X represents a carbonyl group or a methylene group, Y represents a sulfur atom or a vinylene group and pharmaceutically acceptable salts thereof which exhibit a vasodilating activity and inhibitory activity for platelet aggregation.
    Thus, they are useful as therapeutic agents for treat­ment of angina pectoris, hypertension, thrombosis and the like.

    摘要翻译： 由下式表示的新化合物： worin具有1至3个碳原子的烷基的R1 darstellt，氨基的R2 darstellt或下式基团的其中具有1至3个碳原子烷基的R4 darstellt， 具有1至3个碳原子，或者可以与R 6结合以形成五或六元环含4-5个碳原子的烷基的R 5 darstellt，R6代表氢原子或可以与R5结合形成五或六元环含 4至5个碳原子，R 3表示氢原子，在具有1-3个碳原子或卤素原子的烷基，X代表羰基或亚甲基，Y表示硫原子或亚乙烯基，其可药用盐 表现出对血小板聚集的血管舒张活性和抑制活性。 因此，它们是用于治疗心绞痛，高血压，血栓症等的治疗剂。