公开(公告)号：EP1603863B1

公开(公告)日：2010-01-13

申请号：EP02808152.9

申请日：2002-11-20

申请人： Hikal Ltd.

发明人： KUPPUSWAMY, Nagarajan, Hikal R & D centre ,  HARIHARAN, Sivaramakrishnan, Hikal R & D centre ,  MARIADAS, Arulselvan, Hikal R & D centre

IPC分类号： C07C227/42 ,  C07C229/28

CPC分类号： C07C227/18 ,  C07C227/38 ,  C07C2601/14 ,  C07C229/28

摘要： This invention relates to an improved process for the preparation of amino methyl cyclo alkane acetic acids. This invention particularly relates to an improved process for the preparation of gabapentin (which is chemically known as 1-aminomethyl-1-cyclohexaneacetic acid), which is a very well known agent useful for the treatment of epilepsy and other cerebral disorders. In the chemical series of 1-amino methyl cyclo alkane-1-acetic acids, Gabapentin, which is 1-amino methyl cyclo hexane -1-acetic acid has been developed as a drug having anti convulsive properties.

摘要翻译： 本发明涉及一种制备氨基甲基环烷烃乙酸的改进方法。 本发明特别涉及用于制备加巴喷丁（其化学上称为1-氨基甲基-1-环己烷乙酸）的改进方法，其是用于治疗癫痫和其他脑病的非常熟知的药剂。 在1-氨基甲基环烷-1-乙酸的化学系列中，开发了作为1-氨基甲基环己烷-1-乙酸的加巴喷丁作为具有抗惊厥性质的药物。