公开(公告)号：EP4368614A1

公开(公告)日：2024-05-15

申请号：EP22836982.3

申请日：2022-07-06

申请人： Hinova Pharmaceuticals Inc.

发明人： FAN, Lei ,  YU, Hua ,  WANG, Fei ,  AI, Chaowu ,  XU, Kexin ,  LIU, Xingtai ,  DU, Jing ,  PENG, Ying ,  LUO, Tongchuan ,  PENG, Shiming ,  TAN, Bin ,  XIAO, Daibiao ,  HUO, Yongxu ,  LIU, Chengcheng ,  LI, Xinghai ,  CHEN, Yuanwei

IPC分类号： C07D239/48 ,  C07D241/26 ,  C07D249/14 ,  A61P35/00

CPC分类号： A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61K31/55 ,  A61K38/05 ,  A61P35/00 ,  A61P35/02 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D491/107 ,  C07D519/00 ,  C07K5/06017 ,  C07D249/14 ,  C07D239/48 ,  C07D241/26

摘要： A synthesis and an application of a phosphatase degrader, belonging to the field of chemical medicine. The phosphatase degrader is a compound represented by formula I, or a salt thereof, or a deuterated compound thereof, or a stereoisomer thereof, or a solvate thereof, or a hydrate thereof, or a prodrug thereof. The compound can be used as a phosphatase degrader, especially as an SHP2 protein degrader, can treat malignant diseases such as tumors, and has good application prospects.