公开(公告)号：EP3616698A1

公开(公告)日：2020-03-04

申请号：EP18790527.8

申请日：2018-04-19

申请人： Hisamitsu Pharmaceutical Co., Inc.

发明人： KOMINAMI Kazuya ,  SHIMA Takito ,  UCHIDA Naoyuki ,  FUJITA Naoko ,  SUZUKI Shigeo ,  KAIHO Terumitsu

IPC分类号： A61K31/485 ,  A61K9/70 ,  A61K47/22 ,  A61K47/32 ,  A61K47/34 ,  A61P25/04

摘要： A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains a rubber-based adhesive base and a silicone-based adhesive base, and a mass ratio of the rubber-based adhesive base to the silicone-based adhesive base (the mass of the rubber-based adhesive base:the mass of silicone-based adhesive base) in the adhesive layer is 9.5:0.5 to 1.9:8.1.

公开(公告)号：EP3421049B1

公开(公告)日：2020-07-29

申请号：EP16891597.3

申请日：2016-10-26

申请人： Hisamitsu Pharmaceutical Co., Inc.

发明人： IMAMURA Kana ,  FUJITA Naoko ,  MICHINAKA Yasunari

IPC分类号： A61K9/08 ,  A61K31/216 ,  A61K47/02 ,  A61K47/12 ,  A61K47/14 ,  A61P17/00 ,  A61K45/00

公开(公告)号：EP3421049A1

公开(公告)日：2019-01-02

申请号：EP16891597.3

申请日：2016-10-26

申请人： Hisamitsu Pharmaceutical Co., Inc.

发明人： IMAMURA Kana ,  FUJITA Naoko ,  MICHINAKA Yasunari

IPC分类号： A61K45/00 ,  A61K9/08 ,  A61K31/216 ,  A61K47/02 ,  A61K47/12 ,  A61K47/14 ,  A61P17/00

摘要： The present invention provides a liquid topical preparation having low "stickiness" even when it contains a high concentration of an anticholinergic drug. The liquid topical preparation comprises water, an anticholinergic drug and dicarboxylic acid ester, and the content of the anticholinergic drug ranges from 10 mass% to 20 mass% based on the total mass of the liquid topical preparation.