公开(公告)号：EP1172115A1

公开(公告)日：2002-01-16

申请号：EP01906196.9

申请日：2001-02-22

申请人： Hogy Medical Co., Ltd.

发明人： JO, Yoshio ,  AOSHIMA, Motonori ,  TANABE, Koji ,  MATSUSHITA, Koichi ,  INOUE, Toshiki

IPC分类号： A61K38/36 ,  A61K38/37 ,  A61K31/715 ,  A61K9/00 ,  A61K47/38 ,  A61P17/02 ,  A61P7/04 ,  A61L15/16 ,  D06M13/21

CPC分类号： D06M23/06 ,  A61K31/717 ,  A61L15/225 ,  A61L15/28 ,  A61L15/32 ,  A61L2400/04 ,  D06M11/38 ,  D06M13/21 ,  D06M15/15 ,  C08L1/26 ,  C08L89/00 ,  C08L1/00

摘要： Proposed is a novel soluble trauma-healing and hemostatic cellulose fiber capable of absorbing and readily dissolving hemorrhaging trauma loci when applied thereto and of promoting the hemostatic action of blood platelets and fibrin and cell adhesion to the trauma site. The coagulation protein-containing soluble trauma-healing and hemostatic cellulose fiber is produced in that after treatment of a natural or regenerated cellulose fiber with an aqueous sodium hydroxide solution, said fiber is carboxymethylated by reaction with a monochloro acetic acid solution for a given time (hours) in such a manner that the degree of partial substitution of the glucose units constituting the cellulose molecule (etherification degree) is 0.5-less than 1.0% and that, furthermore, the coagulation proteins fibrinogen, thrombin, and coagulation factor XIII are imparted by surface application or chemical bonding.

摘要翻译： 提出了一种新的可溶性创伤愈合止血纤维素纤维并且能够吸收和溶解随手赔了创伤位点当向其施加促销廷和血小板和纤维蛋白和细胞粘附到创伤部位止血作用。 可溶性创伤愈合和止血纤维素纤维凝固含蛋白质在用天然或再生纤维素纤维（在wässrige氢氧化钠溶液的后处理没有产生，所述纤维通过与给定时间的单氯醋酸溶液羧甲基化 小时）（以寻求一个方式也构成纤维素分子的醚化度的葡萄糖单元）的部分取代度为0.5以上且小于1.0％，并且，更进一步，凝固蛋白纤维蛋白原，凝血酶和凝血因子XIII是通过赋予 表面应用或化学键合。

公开(公告)号：EP1172115B1

公开(公告)日：2005-06-29

申请号：EP01906196.9

申请日：2001-02-22

申请人： Hogy Medical Co., Ltd.

发明人： JO, Yoshio ,  AOSHIMA, Motonori ,  TANABE, Koji ,  MATSUSHITA, Koichi ,  INOUE, Toshiki

IPC分类号： A61L15/22 ,  A61L15/32 ,  A61L15/28 ,  A61L15/44 ,  A61K31/715 ,  D06M11/38 ,  D06M13/21 ,  D06M15/15

CPC分类号： D06M23/06 ,  A61K31/717 ,  A61L15/225 ,  A61L15/28 ,  A61L15/32 ,  A61L2400/04 ,  D06M11/38 ,  D06M13/21 ,  D06M15/15 ,  C08L1/26 ,  C08L89/00 ,  C08L1/00

摘要： Novel hemostatic soluble cellulose fibers for treating wound, when applied to a bleeding wound, which absorb moisture therein and are easily dissolved to thereby assist the hemostatic effect and cell adhesion to the wound of blood platelets and fibrin contained in the blood. These hemostatic soluble cellulose fibers for treating wound are prepared by treating natural or regenerated cellulose fiber with an aqueous sodium hydroxide solution, carboxymethylating it by reacting with a monochloroacetic acid solution for a definite period of time in such a manner as to give a partial degree of substitution (degree of etherification) of hydroxyl in the glucose unit constituting the cellulose molecules of from 0.5 to less than 1.0, and applying or chemically bonding a coagulating protein fibrinogen, thrombin or blood coagulation factor XIII.