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公开(公告)号：EP2655390B1
公开(公告)日：2019-03-27
申请号：EP11851169.0
申请日：2011-12-21
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公开(公告)号：EP2655390A2
公开(公告)日：2013-10-30
申请号：EP11851169.0
申请日：2011-12-21
发明人： KYAS, Andreas , FREUND, Ernst , SCHLÖRKE, Oliver , PATERNITI, James, R. , ELLIOTT, Gary , LILL, Jorg , ROGALL, Lars , MENIA, Dario
CPC分类号： C07C62/32 , A61K36/73 , A61K2236/333 , C07H1/08 , C07H13/08 , C07H15/24 , C07J63/008
摘要： A cardiogenin major isomer is obtained from a methanol extract of
Geum japonicum and separated from its minor isomer. The separation of the two isomers can be achieved by chiral phase chromatography, e.g., using a Chiralpak® IC™ column. The purity of the isolated cardiogenin major isomer can be further increased by crystallization, yielding isolated cardiogenin major isomer having HPLC purity as high as 98.97% (a/a) at 210 nm and a potency of 95.50%) (w/w).
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