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公开(公告)号：EP2501381B1
公开(公告)日：2017-07-26
申请号：EP10832058.1
申请日：2010-11-16
申请人： Huya Bioscience International LLC , Shanghai Institute of Materia Medica, Chinese Academy of Sciences
发明人： ELLIOT, Gary, T. , WANG, Yiping , BAI, Donglu
IPC分类号： A61K31/4025 , A61K31/402 , A61K31/40 , A61K9/22 , A61K9/20 , A61K9/08 , A61P9/00 , A61P9/06 , A61K31/18
CPC分类号： A61K31/4025 , A61K31/18 , A61P9/00 , A61P9/06
摘要： Atrial fibrillation (AF) can be treated or prevented by administering to a subject who suffers from or is at risk of suffering from AF a composition comprised of an amount of an active agent, which is 4-methoxy-N-(3,5-bis(1-pyrrolidinyl)-4-hydroxy benzyl)benzene sulfonamide (sulcardine) or a pharmaceutically acceptable salt thereof, such that the Cmax value the active agent in the subject is in the range from about 1 muM to about 20 muM.
摘要翻译： 通过给患有或有患AF风险的受试者施用由一定量的活性剂组成的组合物来治疗或预防心房纤维性颤动（AF），所述活性剂是4-甲氧基-N-（3,5-二 - （1-吡咯烷基）-4-羟基苄基）苯磺酰胺（磺草胺）或其药学上可接受的盐，使得受试者中活性剂的C max值在约1μM至约20μM的范围内。
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公开(公告)号：EP3311810A1
公开(公告)日：2018-04-25
申请号：EP17182709.0
申请日：2010-11-16
申请人： Huya Bioscience International LLC , Shanghai Institute of Materia Medica, Chinese Academy of Sciences
发明人： ELLIOT, Gary, T. , WANG, Yiping , BAI, Donglu
IPC分类号： A61K31/4025 , A61K31/402 , A61K31/40 , A61K9/22 , A61K9/20 , A61K9/08 , A61P9/00 , A61P9/06 , A61K31/18
CPC分类号： A61K31/4025 , A61K31/18 , A61P9/00 , A61P9/06
摘要： Atrial fibrillation (AF) can be treated or prevented by administering to a subject who suffers from or is at risk of suffering from AF a composition comprised of an amount of an active agent, which is 4-methoxy-N-(3,5-bis-(1-pyrrolidinyl)-4-hydroxy benzyl) benzene sulfonamide (sulcardine) or a pharmaceutically acceptable salt thereof, such that the Cmax value the active agent in the subject is in the range from about 1 µM to about 20 µM.
摘要翻译： 通过给患有或有患AF风险的受试者施用由一定量的活性剂组成的组合物来治疗或预防心房纤维性颤动（AF），所述活性剂是4-甲氧基-N-（3,5-二 - （1-吡咯烷基）-4-羟基苄基）苯磺酰胺（磺草胺）或其药学上可接受的盐，使得受试者中活性剂的C max值在约1μM至约20μM的范围内。
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公开(公告)号：EP2501381A2
公开(公告)日：2012-09-26
申请号：EP10832058.1
申请日：2010-11-16
发明人： ELLIOT, Gary, T.
CPC分类号： A61K31/4025 , A61K31/18 , A61P9/00 , A61P9/06
摘要： Atrial fibrillation (AF) can be treated or prevented by administering to a subject who suffers from or is at risk of suffering from AF a composition comprised of an amount of an active agent, which is 4-methoxy-N-(3,5-bis(1-pyrrolidinyl)-4-hydroxy benzyl)benzene sulfonamide (sulcardine) or a pharmaceutically acceptable salt thereof, such that the Cmax value the active agent in the subject is in the range from about 1 muM to about 20 muM.
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