公开(公告)号：EP4434552A1

公开(公告)日：2024-09-25

申请号：EP21820654.8

申请日：2021-11-17

申请人： I+Med S. Coop.

发明人： ANDRADE DEL OLMO, Jon ,  ALONSO CARNICERO, Jose Maria ,  PEREZ GONZALEZ, Raul ,  MUÑOZ MORENTIN, Manuel

IPC分类号： A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16

CPC分类号： A61L27/54 ,  A61L27/34 ,  A61L31/10 ,  A61L29/085 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/6120130101 ,  A61L2300/60820130101 ,  A61L2300/60420130101 ,  A61L2300/40420130101 ,  A61L2300/41420130101 ,  A61L2300/40220130101 ,  A61L2300/41620130101 ,  A61L2430/1220130101 ,  A61L2420/0820130101 ,  A61L2300/40620130101

摘要： A multi-layered coating for coating a surface coating of an implant (20), the multi-layered coating comprising polyelectrolyte layers (13), wherein the polyelectrolyte layers (13) are interspersed layers of a layer that comprises hyaluronic acid and/or its derivatives and a layer that comprises chitosan and/or its derivatives and the multi-layered coating having an external surface (11) with a contact angle between 10° and 50°. A method for coating an implant with a multi-layered coating, the method being a layer by layer coating method, comprising a first step of activation of a surface of the implant to be coated by superficial hydroxyl, carboxylate, aldehyde, epoxide, isothiocyanate, amine, halide, or thiol groups, a second step of generating the multi-layered coating depositing interspersed polyelectrolyte layers (13) of a layer that comprises hyaluronic acid and/or its derivatives and a layer that comprises chitosan and/or its derivatives onto the activated surface to be coated, and a third step of drying the multi-layered coating, the resulting multi-layered coating having an external surface (11) with a contact angle between 10° and 50°.