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公开(公告)号：EP0663591A1
公开(公告)日：1995-07-19
申请号：EP94309361.7
申请日：1994-12-14
发明人： Gratton, Enrico , Fantini, Sergio , Franceschini, Maria Angela , Mantulin, William , Barbieri, Beniamino , Maier, John , Walker, Scott A.
CPC分类号： G01N21/314 , A61B5/0059 , A61B5/14532 , A61B5/1455 , A61B5/14552 , A61B5/6824 , A61B2562/0233 , A61B2562/046 , G01N21/49
摘要： The quantitative determination of various materials in highly scattering media such as living tissue may be determined in an external, photometric manner by the use of a plurality of light sources positioned at differing distances from a sensor. The light from said sources is amplitude modulated, and, in accordance with conventional frequency domain fluorometry or phosphorimetry techniques, the gain of the sensor is modulated at a frequency different from the frequency of the light modulation. Data may be acquired from each of the light sources at differing distances at a frequency which is the difference between the two frequencies described above. From these sets of data from each individual light source, curves may be constructed, and the slopes used to quantitatively determine the amount of certain materials present, for example oxyhemoglobin and deoxyhemoglobin in living tissue, or to determine at least the relative concentration of a material such as glucose.
摘要翻译： 可以通过使用位于与传感器不同的距离的多个光源以外部的光度方式来确定诸如活组织的高度散射介质中的各种材料的定量测定。 来自所述源的光被幅度调制，并且根据常规的频域荧光测定或荧光测定技术，传感器的增益以与光调制频率不同的频率被调制。 可以以与上述两个频率之间的差异的频率以不同的距离从每个光源获取数据。 根据来自每个单独光源的这些数据集，可以构建曲线，并且用于定量确定存在的某些材料的量的斜率，例如活组织中的氧合血红蛋白和脱氧血红蛋白，或至少确定材料的相对浓度 如葡萄糖。
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公开(公告)号：EP0663591B1
公开(公告)日：2002-06-12
申请号：EP94309361.7
申请日：1994-12-14
发明人： Gratton, Enrico , Fantini, Sergio , Franceschini, Maria Angela , Mantulin, William , Barbieri, Beniamino , Maier, John , Walker, Scott A.
CPC分类号： G01N21/314 , A61B5/0059 , A61B5/14532 , A61B5/1455 , A61B5/14552 , A61B5/6824 , A61B2562/0233 , A61B2562/046 , G01N21/49
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