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公开(公告)号：EP0189305A3
公开(公告)日：1988-10-05
申请号：EP86300379
申请日：1986-01-20
申请人： ICI AMERICAS INC.
发明人： Bergeson, Scott Haven , Schwartz, John Anthony , Stein, Mark Morris , Wildonger, Richard Alan , Edwards, Philip Duke , Shaw, Andrew , Trainor, Diane Amy , Wolanin, Donald John
CPC分类号： C07C205/26 , A61K38/00 , C07C205/02 , C07C205/43 , C07K5/06191 , C07K5/0819 , C07K5/0827
摘要： The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae la, lb, lc set out hereinafter, and salts thereof, which are inhibitors of humanleukocyte elastase. Also described herein are pharmaceutical compositions containing apeptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.
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公开(公告)号：EP0189305B1
公开(公告)日：1992-07-29
申请号：EP86300379.4
申请日：1986-01-20
申请人： ICI AMERICAS INC.
发明人： Bergeson, Scott Haven , Schwartz, John Anthony , Stein, Mark Morris , Wildonger, Richard Alan , Edwards, Philip Duke , Shaw, Andrew , Trainor, Diane Amy , Wolanin, Donald John
CPC分类号： C07C205/26 , A61K38/00 , C07C205/02 , C07C205/43 , C07K5/06191 , C07K5/0819 , C07K5/0827
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公开(公告)号：EP0189305A2
公开(公告)日：1986-07-30
申请号：EP86300379.4
申请日：1986-01-20
申请人： ICI AMERICAS INC.
发明人： Bergeson, Scott Haven , Schwartz, John Anthony , Stein, Mark Morris , Wildonger, Richard Alan , Edwards, Philip Duke , Shaw, Andrew , Trainor, Diane Amy , Wolanin, Donald John
CPC分类号： C07C205/26 , A61K38/00 , C07C205/02 , C07C205/43 , C07K5/06191 , C07K5/0819 , C07K5/0827
摘要： The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae la, lb, lc set out hereinafter, and salts thereof, which are inhibitors of humanleukocyte elastase. Also described herein are pharmaceutical compositions containing apeptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.
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