公开(公告)号：EP2044044A2

公开(公告)日：2009-04-08

申请号：EP07812086.2

申请日：2007-06-08

申请人： ICOS CORPORATION

发明人： DUDLER, Thomas ,  FAROUZ, Francine ,  FOWLER, Kerry ,  HAWTHORN, Nataly ,  HUANG, Danwen ,  JUDKINS, Angela ,  KIM, Musong ,  ODINGO, Joshua ,  OLIVER, Amy ,  REED, Mark ,  RUAN, Fuqiang ,  THORSETT, Eugene

IPC分类号： C07D295/16

CPC分类号： C07D295/205 ,  C07D207/273 ,  C07D211/46 ,  C07D211/54 ,  C07D211/76 ,  C07D213/71 ,  C07D215/36 ,  C07D223/12 ,  C07D225/02 ,  C07D239/42 ,  C07D241/08 ,  C07D261/10 ,  C07D295/155 ,  C07D295/185 ,  C07D295/26 ,  C07D313/12 ,  C07D333/34 ,  C07D405/04

摘要： Substituted phenyl acetic acid compounds of formula (I), pharmaceutical compositions, methods for their preparation and methods are provided that are useful in the treatment and prevention of disorders or conditions responsive to DP 2 receptor modulation, in particular, inflammatory and immune related disorders and conditions, such as asthma, allergic rhinitis and atopic dermatitis.

摘要翻译： 提供式（I）的取代的苯乙酸化合物，药物组合物，其制备方法和方法，其可用于治疗和预防对DP 2受体调节响应的病症或病症，特别是与炎症和免疫相关的病症和 如哮喘，过敏性鼻炎和特应性皮炎。

公开(公告)号：EP2044017A2

公开(公告)日：2009-04-08

申请号：EP07812087.0

申请日：2007-06-08

申请人： ICOS CORPORATION

发明人： DUDLER, Thomas ,  FAROUZ, Francine ,  FOWLER, Kerry ,  HAWTHORN, Nataly ,  HUANG, Danwen ,  BOHAN, Jin ,  KIM, Musong ,  LOVER, Andrew ,  ODINGO, Joshua ,  OLIVER, Amy ,  REED, Mark ,  RUAN, Fuqiang ,  THORSETT, Eugene

IPC分类号： C07D209/18 ,  C07D211/30 ,  C07D211/96 ,  C07D217/06 ,  C07D223/04 ,  C07D401/12 ,  C07D407/12 ,  C07D409/12

CPC分类号： C07D267/14 ,  C07D207/337 ,  C07D211/34 ,  C07D217/06 ,  C07D217/08 ,  C07D223/04 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

摘要： Substituted phenyl acetic acid compounds of formula (I), pharmaceutical compositions, methods for their preparation and methods are provided that are useful in the treatment and prevention of disorders or conditions responsive to DP-2 receptor modulation, in particular, inflammatory and immune-related disorders and conditions, such as asthma, allergic rhinitis and atopic dermatitis.

公开(公告)号：EP2220089A2

公开(公告)日：2010-08-25

申请号：EP08850176.2

申请日：2008-11-12

申请人： ICOS CORPORATION

发明人： WHITE, Stephen, L. ,  RUAN, Fuqiang ,  KESICKI, Edward, A. ,  THORSETT, Eugene ,  FAROUZ, Francine

IPC分类号： C07D487/04 ,  C07D487/02 ,  C07D403/08 ,  C07D403/12

CPC分类号： C07D519/00

摘要： Compounds that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3Kδ plays a role in leukocyte function, using the compounds also are disclosed.