公开(公告)号：EP1869020B1

公开(公告)日：2010-12-01

申请号：EP06748900.5

申请日：2006-03-29

申请人： ICOS Corporation

发明人： DIAZ, Frank ,  FAROUZ, Francine, S. ,  HOLCOMB, Ryan ,  KESICKI, Edward, A. ,  OOI, Hua, Chee ,  RUDOLPH, Alexander ,  STAPPENBECK, Frank ,  THORSETT, Eugene ,  GAUDINO, John, Joseph ,  FISHER, Kimba, L. ,  COOK, Adam, Wade

IPC分类号： C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  A61K31/497 ,  A61K31/5355 ,  A61K31/541 ,  A61P35/00

CPC分类号： C07D413/12 ,  C07D403/12 ,  C07D417/12

摘要： Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division, also are disclosed.

摘要翻译： 公开了可用于治疗与DNA复制中的DNA损伤或病变有关的疾病和病症的取代脲化合物。 还公开了制备这些化合物的方法以及它们作为治疗剂的用途，例如用于治疗癌症和其他以DNA复制，染色体分离或细胞分裂缺陷为特征的疾病。

公开(公告)号：EP1869020A1

公开(公告)日：2007-12-26

申请号：EP06748900.5

申请日：2006-03-29

申请人： ICOS Corporation

发明人： DIAZ, Frank ,  FAROUZ, Francine, S. ,  HOLCOMB, Ryan ,  KESICKI, Edward, A. ,  OOI, Hua, Chee ,  RUDOLPH, Alexander ,  STAPPENBECK, Frank ,  THORSETT, Eugene ,  GAUDINO, John, Joseph ,  FISHER, Kimba, L. ,  COOK, Adam, Wade

IPC分类号： C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  A61K31/497 ,  A61K31/5355 ,  A61K31/541 ,  A61P35/00

CPC分类号： C07D413/12 ,  C07D403/12 ,  C07D417/12

摘要： Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division, also are disclosed.

摘要翻译： 公开了可用于治疗与DNA复制中的DNA损伤或病变有关的疾病和病症的取代脲化合物。 还公开了制备这些化合物的方法以及它们作为治疗剂的用途，例如用于治疗癌症和其他以DNA复制，染色体分离或细胞分裂缺陷为特征的疾病。

公开(公告)号：EP1778648A2

公开(公告)日：2007-05-02

申请号：EP05810303.7

申请日：2005-08-18

申请人： ICOS Corporation

发明人： FAROUZ, Francine S. ,  HOLCOMB, Ryan ,  THORSETT, Eugene ,  GAUDINO, John Joseph

IPC分类号： C07D241/20 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  A61K31/4965 ,  A61K31/497 ,  A61P35/00

CPC分类号： C07D241/20 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04

摘要： Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.