公开(公告)号：EP0150099A1

公开(公告)日：1985-07-31

申请号：EP85300294.7

申请日：1985-01-16

申请人： IMPERIAL CHEMICAL INDUSTRIES PLC ,  ICI AMERICAS INC.

发明人： Kirkland, Karin Monson ,  Mant, Derrick Michael

IPC分类号： C07D231/40 ,  C07D261/14 ,  C07D275/02 ,  C07D233/88 ,  C07D285/08 ,  C07D271/06 ,  C07D249/04 ,  C07D277/48 ,  C07D249/08 ,  C07D241/20 ,  C07D213/75

CPC分类号： C07D231/38 ,  C07D231/16 ,  C07D231/40

摘要： A guanidine derivative of the formula l:-
in which R 1 , R 2 , R 3 , R 4 , ring X and D are a variety of radicals defined in the specification and A is a 3-8C alkylene chain which is substituted by a hydroxy radical and into which is optionally inserted, as part of the backbone of the chain, one or two groups selected from oxygen and sulphur atoms and NH and 1-6C N-alkyl radicals; and the pharmaceutically-acceptable acid additions salts thereof. Pharmaceutical compositions and methods of manufacture are also described. The compound of the formula I is a histamine H-2 antagonist and is therefore useful in ulcer therapy.