公开(公告)号：EP0820512A1

公开(公告)日：1998-01-28

申请号：EP96912728.0

申请日：1996-04-12

申请人： INCYTE PHARMACEUTICALS, INC.

发明人： BANDMAN, Olga ,  COLEMAN, Roger ,  STUART, Susan, G. ,  BRAXTON, Scott, Michael ,  RHODES, Eric, T. ,  COCKS, Benjamin, Graem

IPC分类号： G01N33 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N15 ,  C12P21 ,  C12Q1 ,  A61K38

CPC分类号： C07K14/523 ,  A61K38/00

摘要： The present invention relates to novel nucleotide and amino acid sequences for a novel C-C chemokine initially found in a cDNA library from blood cells of an individual having Hypereosinophilic Syndrome. The present invention also provides for antisense molecules to the nucleotide sequences which encode EEC, expression vectors for the production of purified EEC, antibodies capable of binding specifically to EEC, hybridization probes or oligonucleotides for the detection of EEC-encoding nucleotide sequences EEC, diagnostic tests for chemokine activation based on EEC-encoding nucleic acid molecules and antibodies capable of binding specifically to EEC.