-
1.发明授权Cloning, yeast expression, purification and biological activity of the extension region of the soybean 7S globulin alfa' subunit involved in Hep G2 cell cholesterol homeostasis 有权克隆，酵母表达，纯化和大豆7S球蛋白α-亚基的扩展区域，其参与的Hep G2细胞胆固醇稳态的生物活性
公开(公告)号：EP2264055B1
公开(公告)日：2014-03-26
申请号：EP09162939.4
申请日：2009-06-17
申请人： Indena S.p.A.
发明人： Morazzoni, Paolo , Riva, Antonella , Ponzone, Cesare , Berlanda, Davide , Duranti, Marcello , Consonni, Alessandro
IPC分类号： C07K14/415
CPC分类号： C07K14/415
-
2.发明公开Cynara scolymus extracts and compositions containing them 审中-公开Extrakte aus Cynara scolymus und Zusammensetzungen damit
公开(公告)号：EP1967199A1
公开(公告)日：2008-09-10
申请号：EP07425133.1
申请日：2007-03-07
申请人： Indena S.p.A.
发明人： Bombardelli, Ezio , Fontana, Gabriele , Giori, Andrea , Morazzoni, Paolo , Ponzone, Cesare , Ronchi, Massimo
CPC分类号： A61K36/28
摘要： The present invention relates to a Cynara scolymus extract with a high caffeoylquinic acid content, obtainable by extraction from undried globe artichoke heads with alcohols having up to three carbon atoms.
摘要翻译： 本发明涉及具有高咖啡酰奎宁酸含量的Cynara scolymus提取物，其通过从具有至多3个碳原子的醇从未干燥的朝鲜蓟头提取而获得。
-
3.发明公开Cloning, yeast expression, purification and biological activity of the extension region of the soybean 7S globulin alfa' subunit involved in Hep G2 cell cholesterol homeostasis 有权克隆，酵母表达，纯化和大豆7S球蛋白α-亚基的扩展区域，其参与的Hep G2细胞胆固醇稳态的生物活性
公开(公告)号：EP2264055A1
公开(公告)日：2010-12-22
申请号：EP09162939.4
申请日：2009-06-17
申请人： Indena S.p.A.
发明人： Morazzoni, Paolo , Riva, Antonella , Ponzone, Cesare , Berlanda, Davide , Duranti, Marcello , Consonni, Alessandro
IPC分类号： C07K14/415
CPC分类号： C07K14/415
摘要： A truncated form of α' chain (eα'), the soybean 7S globulin, active in controlling the cholesterol and triglyceride homeostasis in in vitro and in vivo models, was cloned and expressed in the yeast Pichia pastoris. The recombinant polypeptide spanned 142 amino acid residues from the N-terminal side and included the N-terminal extension region of the soybean alpha' subunit. The eα' polypeptide was purified by conventional biochemical techniques and its potential to modulate the activity of the LDL-receptor was evaluated in a human hepatoma cell line (Hep G2) by monitoring the uptake and degradation of labeled LDL.
摘要翻译： ±“链（一个或多个±”），大豆7S球蛋白的截短形式，活性在控制的体外胆固醇和甘油三酯稳态和体内模型，其克隆并在酵母巴斯德毕赤酵母中过表达。 重组多肽从N末端侧跨越142个氨基酸残基和包含在大豆的α“亚基的N端延伸区域。 其通过常规生化技术纯化电子±“多肽及其潜在通过监视摄取和标记的LDL的降解来调节其在人肝癌细胞系（Hep G2细胞）来评价LDL受体的活性。
-
4.发明授权
公开(公告)号：EP1967198B1
公开(公告)日：2009-05-13
申请号：EP07425132.3
申请日：2007-03-07
申请人： Indena S.p.A.
发明人： Bombardelli, Ezio , Fontana, Gabriele , Giori, Andrea , Morazzoni, Paolo , Ponzone, Cesare , Ronchi, Massimo
CPC分类号： A61K36/28 , A61K31/353 , A61K36/185 , A61K36/48 , A61K2300/00
-
5.发明公开Cloning, yeast expression, purification and biological activity of a truncated form of the soybean 7S globulin alfa ' subunit involved in Hep G2 cell cholesterol homeostasis 审中-公开克隆，酵母表达，纯化和其参与的Hep G2细胞胆固醇稳态的大豆7S球蛋白α-亚基的截短形式的生物活性
公开(公告)号：EP2264054A1
公开(公告)日：2010-12-22
申请号：EP09162935.2
申请日：2009-06-17
申请人： Indena S.p.A.
发明人： Morazzoni, Paolo , Riva, Antonella , Ponzone, Cesare , Berlanda, Davide , Duranti, Marcello , Consonni, Alessandro
IPC分类号： C07K14/415
CPC分类号： C07K14/415
摘要： A truncated form of α' chain (tα'), the soybean 7S globulin, active in controlling the cholesterol and triglyceride homeostasis in in vitro and in vivo models, was cloned and expressed in the yeast Pichia pastoris. The recombinant polypeptide spanned 216 amino acid residues from the N-terminal side and included the N-terminal extension region of the soybean subunit. The tα' polypeptide was purified by conventional biochemical techniques and its potential to modulate the activity of the LDL-receptor was evaluated in a human hepatoma cell line (Hep G2) by monitoring the uptake and degradation of labeled LDL. The LDL uptake (+ 192%) and degradation (+ 143%) by cells tested at the highest tα' dose (8 µM) were similar to those found in cells incubated with 1 µM simvastatin, a potent inhibitor of cholesterol biosynthesis. The cell response to tα' was found to be dose-dependent.
摘要翻译： ±“链的截短形式（T±），大豆7S球蛋白，活性在控制的体外胆固醇和甘油三酯稳态和体内模型，其克隆并在酵母巴斯德毕赤酵母中过表达。 重组多肽从N末端侧跨越216个氨基酸残基和包含在大豆亚基的N端延伸区域。 其通过常规生化技术纯化吨±“多肽及其潜在通过监视摄取和标记的LDL的降解来调节其在人肝癌细胞系（Hep G2细胞）来评价LDL受体的活性。 的LDL摄取（+ 192％）和降解（+ 143％）通过在最高吨±“剂量（8 UM）测试过的细胞的那些相似与1μM的辛伐他汀，胆固醇生物合成的有效抑制剂孵育的细胞中发现。 的细胞应答至t±“被发现是剂量依赖性的。
-
6.发明公开Formulations of alpha-amylase inhibitors of P. vulgaris with alpha-glucosidade inhibitores of S. oblonga or S. reticulata useful in the treatment of diabetes and obesity 审中-公开从P.α-淀粉酶抑制剂的制剂与S矩或S.网状的α-葡萄糖苷酶抑制剂为寻常糖尿病和肥胖症的治疗
公开(公告)号：EP1967200A1
公开(公告)日：2008-09-10
申请号：EP07425134.9
申请日：2007-03-07
申请人： Indena S.p.A.
CPC分类号： A61K36/48 , A23L33/105 , A23V2002/00 , A61K36/37 , A61K2300/00 , A23V2200/328 , A23V2200/332 , A23V2250/21
摘要： This invention relates to the combination of α-amylase inhibitors prepared from Phaseolus vulgaris with α-glucosidase inhibitors obtained from Salacia oblonga and other species. The α-amylase inhibitor is accompanied by a quantity of lectins that reduces the amount of glucose originating from the starches present in the diet, and considerably reduces the appetite after repeated administration. The combination with α-glucosidase inhibitors, such as extracts of Salacia or the thiosugars present in it, further reduce the blood glucose, acting synergically, and consequently reduce the synthesis of fats from carbohydrates.
摘要翻译： 本发明涉及的来自菜豆制备与长圆五层龙和其他物种获得±葡糖苷酶抑制剂寻常±淀粉酶抑制剂的组合。 的±淀粉酶抑制剂伴随凝集素的量减少没葡萄糖从存在于饮食中的淀粉源自量，并显着降低了重复给药后的食欲。 具有±葡糖苷酶抑制剂，颜色的组合：如五层龙或存在于它的thiosugars的提取物，进一步降低血糖，协同地起作用，并因此减少从碳水化合物脂肪的合成。
-
7.发明公开Formulations containing cynara scolymus and phaseolus vulgaris extracts which are useful in the treatment of obesity 有权Formulierungen mit Extrakten aus Cynara scolymus und Phaseolus vulgaris zur Behandlung von Adipositas
公开(公告)号：EP1967198A1
公开(公告)日：2008-09-10
申请号：EP07425132.3
申请日：2007-03-07
申请人： Indena S.p.A.
发明人： Bombardelli, Ezio , Fontana, Gabriele , Giori, Andrea , Morazzoni, Paolo , Ponzone, Cesare , Ronchi, Massimo
CPC分类号： A61K36/28 , A61K31/353 , A61K36/185 , A61K36/48 , A61K2300/00
摘要： The present invention relates to a Cynara scolymus extract with a high content of caffeoylquinic acids, and a composition containing said Cynara scolymus extract with a Phaseolus vulgaris extract.
Said composition is useful in reducing obesity as it reduces cholesterol, triglycerides and blood glucose by sensitising the cells to insulin. This combination, when taken before meals, reduces the appetite, leading to a reduction in body weight. The extracts are preferably formulated in Oenothera biennis oil, fish oil, or oils rich in unsaturated ω-3 fatty acids.摘要翻译： 本发明涉及具有高含量咖啡酰奎宁酸的Cynara scolymus提取物，以及含有所述Cynara scolymus提取物与菜豆提取物的组合物。 所述组合物可用于减少肥胖症，因为其通过使细胞对胰岛素敏感而降低胆固醇，甘油三酯和血糖。 这种组合在饭前服用时会降低食欲，导致体重下降。 提取物优选配制在含有不饱和É-3脂肪酸的欧烯二酸油，鱼油或油中。
-
8.发明授权Cosmetic and/or pharmaceutical compositions and methods for their use in protecting tissues from contact with heavy metals 失效化妆品和/或药物制剂和它们的使用方法在保护组织针对与重金属接触
-
9.发明公开Cosmetic and/or pharmaceutical compositions and methods for their use in protecting tissues from contact with heavy metals 失效化妆品和/或药物制剂以及它们在保护组织针对与重金属接触使用方法。
公开(公告)号：EP0557042A1
公开(公告)日：1993-08-25
申请号：EP93301087.8
申请日：1993-02-16
申请人： INDENA S.p.A.
摘要： Topical cosmetic and pharmaceutical compositions are provided for the external protection of human or animal tissues from contact with heavy metals, and said composition comprising a metal sequestering component capable of binding metal ions and a physiologically inert carrier suitable for topical administration. The said metal sequestering component comprises one or more metal binding peptide having a high proportion of cysteine residues, for example a metallothionein.
摘要翻译： 提供了用于从接触重金属人体或动物组织的外部保护局部化妆品和药物组合物，和所述组合物包含能够结合金属离子的且适于局部施用的生理上惰性的载体的金属截存组分。 所述金属螯合剂组分包括具有半胱氨酸残基的比例高，例如金属硫蛋白的一种或多种金属结合肽。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.01 秒)
