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    DEVICE AND METHOD FOR DETECTING AND IDENTIFYING EXTRACELLULAR VESICLES IN A LIQUID DISPERSION SAMPLE
    2.
    发明公开
    DEVICE AND METHOD FOR DETECTING AND IDENTIFYING EXTRACELLULAR VESICLES IN A LIQUID DISPERSION SAMPLE 审中-公开

    公开(公告)号：EP4296646A2

    公开(公告)日：2023-12-27

    申请号：EP23207812.1

    申请日：2019-10-31

    申请人： INESC TEC - Instituto de Engenharia de Sistemas e Computadores, Tecnologia e Ciência

    发明人： DOS SANTOS PAIVA, Joana Isabel ,  TRIGUEIROS DA SILVA CUNHA, João Paulo ,  DA SILVA JORGE, Pedro Alberto

    IPC分类号： G01N15/10

    摘要： Device and method for detecting dispersed extracellular vesicles in a liquid dispersion sample, said method using an electronic data processor for classifying the sample as having, or not having, extracellular vesicles present, the method comprising the use of the electronic data processor for pre-training a machine learning classifier with a plurality of extracellular vesicle liquid dispersion specimens comprising the steps of: emitting a laser modulated by a modulation frequency onto each specimen; capturing a temporal signal from laser light backscattered by each specimen for a plurality of temporal periods of a predetermined duration for each specimen; calculating specimen DCT or Wavelet transform coefficients from the captured signal for each of the temporal periods; using the calculated coefficients to pre-train the machine learning classifier; wherein the method further comprises the steps of: using a laser emitter having a focusing optical system coupled to the emitter to emit a laser modulated by a modulation frequency onto the sample; using a light receiver to capture a signal from laser light backscattered by the sample for a plurality of temporal periods of a predetermined duration; calculating sample DCT or Wavelet transform coefficients from the captured signal for each of the temporal periods; using the pre-trained machine learning classifier to classify the calculated sample coefficients as having, or not having, extracellular vesicles present.

    DEVICE AND METHOD FOR DETECTING AND IDENTIFYING EXTRACELLULAR VESICLES IN A LIQUID DISPERSION SAMPLE
    3.
    发明公开
    DEVICE AND METHOD FOR DETECTING AND IDENTIFYING EXTRACELLULAR VESICLES IN A LIQUID DISPERSION SAMPLE 审中-实审

    公开(公告)号：EP4296646A3

    公开(公告)日：2024-03-13

    申请号：EP23207812.1

    申请日：2019-10-31

    申请人： INESC TEC - Instituto de Engenharia de Sistemas e Computadores, Tecnologia e Ciência

    发明人： DOS SANTOS PAIVA, Joana Isabel ,  TRIGUEIROS DA SILVA CUNHA, João Paulo ,  DA SILVA JORGE, Pedro Alberto

    IPC分类号： G01N15/0205 ,  G01N15/10 ,  G01N15/1429 ,  G01N15/14

    摘要： Device and method for detecting dispersed extracellular vesicles in a liquid dispersion sample, said method using an electronic data processor for classifying the sample as having, or not having, extracellular vesicles present, the method comprising the use of the electronic data processor for pre-training a machine learning classifier with a plurality of extracellular vesicle liquid dispersion specimens comprising the steps of: emitting a laser modulated by a modulation frequency onto each specimen; capturing a temporal signal from laser light backscattered by each specimen for a plurality of temporal periods of a predetermined duration for each specimen; calculating specimen DCT or Wavelet transform coefficients from the captured signal for each of the temporal periods; using the calculated coefficients to pre-train the machine learning classifier; wherein the method further comprises the steps of: using a laser emitter having a focusing optical system coupled to the emitter to emit a laser modulated by a modulation frequency onto the sample; using a light receiver to capture a signal from laser light backscattered by the sample for a plurality of temporal periods of a predetermined duration; calculating sample DCT or Wavelet transform coefficients from the captured signal for each of the temporal periods; using the pre-trained machine learning classifier to classify the calculated sample coefficients as having, or not having, extracellular vesicles present.