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公开(公告)号：EP3353196A1
公开(公告)日：2018-08-01
申请号：EP16775121.3
申请日：2016-09-21
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Fondation Imagine , Assistance Publique-Hôpitaux de Paris (APHP) , Université Paris Descartes , Centre National de la Recherche Scientifique (CNRS) , Université de Bourgogne , CNAM-CONSERVATOIRE NATIONAL DES ARTS ET METIERS
发明人： BELAID-CHOUCAIR, Zakia , HERMINE, Olivier , MONTES, Matthieu , GARRIDO-FLEURY, Carmen , SEIGNEURIC, Renaud , MARCION, Guillaume
IPC分类号： C07K14/575 , C07K14/72 , C07K14/705
CPC分类号： C07K14/475 , A61K38/1866 , A61K39/3955 , A61K2039/505 , A61P35/00 , C07K14/5759 , C07K14/705 , C07K14/72 , C07K16/22 , C07K2317/76
摘要： The present invention relates to agents capable of inhibiting the binding between Leptin and Neuropilin-1 (NRP1) and uses thereof in the therapeutic field.
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2.发明公开
公开(公告)号：EP3155431A1
公开(公告)日：2017-04-19
申请号：EP15728015.7
申请日：2015-06-12
IPC分类号： G01N33/574
CPC分类号： G01N33/57488 , A61K38/08 , G01N2333/47
摘要： The invention relates to methods for diagnosing cancer and determining the responsiveness to chemotherapyin a subject based on the detection of HSP70-expressing exosomes in a bodily fluid sample obtained from said subject. The invention also relates to methods for treating cancer and in particular methods for restoring or enhancing the anti-tumor immune response in a patient in need thereof by inhibiting the activation MDSC as well as methods for inhibiting or reducing HSP70-expressing exosomes-mediated tumor resistance against a chemotherapeutic agent and therefore methods for restoring or enhancing the efficacy of said chemotherapeutic agent.
摘要翻译： 本发明涉及用于诊断癌症和确定性采矿的响应到chemotherapyin基于表达从所述受试者获得的体液样品中的外泌体的检测HSP70的受试者的方法。 因此，本发明涉及的方法用于治疗癌症和在用于恢复或通过抑制活化MDSC以及用于抑制或减少HSP70表达的方法提高在有需要的患者的抗肿瘤免疫应答的具体方法的外来体介导的肿瘤抗性 对化学治疗剂和用于恢复或增强化疗剂的功效的方法THEREFORE所述。
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