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公开(公告)号：EP3019610B1
公开(公告)日：2020-05-06
申请号：EP14737236.1
申请日：2014-07-08
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Fondation Imagine , Université de Paris , Assistance Publique-Hôpitaux de Paris (APHP)
IPC分类号： C12N15/113 , A61K31/7088
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2.发明公开METHODS FOR PERFORMING ANTISENSE OLIGONUCLEOTIDE-MEDIATED EXON SKIPPING IN THE RETINA OF A SUBJECT IN NEED THEREOF 审中-公开程序OLIGONUKLEOTIDVERMITTELTEM反义外显子跳跃的IN事实指示实体的视网膜上的实现
公开(公告)号：EP3019610A1
公开(公告)日：2016-05-18
申请号：EP14737236.1
申请日：2014-07-08
申请人： INSERM - Institut National de la Santé et de la Recherche Médicale , Fondation Imagine , Université Paris Descartes - Paris V , Assistance Publique-Hôpitaux de Paris (APHP)
IPC分类号： C12N15/113 , A61K31/7088
摘要： A method, an apparatus, and a computer program product for wireless communication are provided. The apparatus determines an observed bit rate based on uplink transmissions of the UE, estimates an available link capacity for the UE, selects an estimate factor, and estimates available uplink throughput for future uplink transmissions of the UE as a function of the observed bit rate, the estimated available link capacity, and the estimate factor.
摘要翻译： 本发明涉及一种用于在需要其的受试者的视网膜进行反义寡核苷酸 - 介导的外显子跳跃的方法。 特别地，本发明涉及用于在受试者中包括注入所述受试者对所述反义寡核苷酸的量的玻璃体的步骤的视网膜细胞进行反义寡核苷酸 - 介导的外显子跳跃的方法。
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公开(公告)号：EP3959315A1
公开(公告)日：2022-03-02
申请号：EP20719658.5
申请日：2020-04-24
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Fondation Asile Des Aveugles , Université de Paris , Assistance Publique Hôpitaux de Paris , Fondation Imagine
IPC分类号： C12N15/113 , C12N15/11
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4.发明公开
公开(公告)号：EP3702461A1
公开(公告)日：2020-09-02
申请号：EP20168215.0
申请日：2014-07-08
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM , Université de Paris , Fondation Imagine , ASSISTANCE PUBLIQUE, HOPITAUX DE PARIS
IPC分类号： C12N15/113 , A61K31/7088
摘要： The present invention relates to methods for performing antisense oligonucleotide-mediated exon skipping in the retina of a subject in need thereof. In particular, the present invention relates to a method for performing antisense oligonucleotide-mediated exon skipping in a retina cell of a subject comprising the step of injecting into the vitreous of the subject an amount of the antisense oligonucleotide.
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