公开(公告)号：EP3024476A1

公开(公告)日：2016-06-01

申请号：EP14749736.6

申请日：2014-07-25

申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Université du Droit et de la Santé de Lille 2 ,  Centre National de la Recherche Scientifique (CNRS) ,  Institut Pasteur De Lille ,  Université de Lille 1 Sciences et Technologies ,  ETH Zurich ,  Universidad de la Republica

发明人： HARDT, Wolf-Dietrich ,  KAISER, Patrick ,  SIRARD, Jean-Claude ,  CARNOY, Christophe ,  FOUGERON, Delphine ,  CHABALGOITY, Jose Alejandro ,  MUÑOZ, Natalia

IPC分类号： A61K38/16 ,  A61K45/06 ,  A61K31/43 ,  A61K31/505 ,  A61K31/635 ,  A61K31/04

CPC分类号： A61K38/164 ,  A61K31/42 ,  A61K31/43 ,  A61K31/505 ,  A61K31/635 ,  A61K45/06 ,  Y02A50/402 ,  Y02A50/475 ,  Y02A50/481 ,  A61K2300/00

摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial infections. In particular, the present invention relates to a Toll-like receptor (TLR) agonist for use in a method for the treatment of a bacterial infection in a subject in need thereof wherein the TLR agonist is administered to the subject in combination with at least one antibiotic.

公开(公告)号：EP3632458A1

公开(公告)日：2020-04-08

申请号：EP19207885.5

申请日：2014-07-25

申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Institut fur Biomedizinische Technik der Universitat und ETH Zurich ,  Institut Pasteur De Lille ,  Université de Lille ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS- ,  Universidad de la Republica Oriental del Uruguay

发明人： SIRARD, Jean-Claude ,  CHABALGOITY, Jose Alejandro ,  HARDT, Wolf-Dietrich ,  KAISER, Patrick ,  CARNOY, Christophe ,  FOUGERON, Delphine ,  MUNOZ, Natalia

IPC分类号： A61K38/16 ,  A61K45/06 ,  A61K31/43 ,  A61K31/505 ,  A61K31/635 ,  A61P31/04

摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial infections. In particular, the present invention relates to a Toll-like receptor (TLR) agonist for use in a method for the treatment of a bacterial infection in a subject in need thereof wherein the TLR agonist is administered to the subject in combination with at least one antibiotic.

公开(公告)号：EP3976756A1

公开(公告)日：2022-04-06

申请号：EP20727688.2

申请日：2020-05-28

申请人： ETH Zurich

发明人： WETTER, Emma ,  DIARD, Médéric ,  HARDT, Wolf-Dietrich

IPC分类号： C12N1/20 ,  C12N9/10 ,  A61K39/02

公开(公告)号：EP3744828A1

公开(公告)日：2020-12-02

申请号：EP19177251.6

申请日：2019-05-29

申请人： ETH Zurich

发明人： WETTER, Emma ,  DIARD, Médéric ,  HARDT, Wolf-Dietrich

IPC分类号： C12N1/20 ,  C12N9/10 ,  A61K39/02

摘要： The present invention relates to an immunogenic composition for Proteobacteria protection and reduced transmission. We have identified Proteobacteria strain combinations that generate an immune response capable of robustly driving bacterial enteropathogens into an evolutionary dead end and reducing the transmission of the bacterium. These inactivated immunogenic compositions and typically oral vaccines are easy to apply, cheap to produce, and can be stored long-term without cold-chain requirements making them ideal for application in livestock, or in resource-poor areas. They are believed to be the only immunogenic compositions and vaccine formulations capable of breaking the chain of transmission for these types of pathogen.