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公开(公告)号:EP3328826A1
公开(公告)日:2018-06-06
申请号:EP16744734.1
申请日:2016-07-26
申请人: INSERM - Institut National de la Santé et de la Recherche Médicale , Assistance Publique-Hôpitaux de Paris , Centre National de la Recherche Scientifique (CNRS) , Universite Paris-Sud
发明人: HUMBERT, Marc , COHEN-KAMINSKY, Sylvia , DUMAS, Sébastien , BRU-MERCIER, Gilles , ALAMI, Mouad , BRION, Jean-Daniel , MESSAOUDI, Samir , GALVANI, Gilles
IPC分类号: C07C211/62 , C07C211/63
摘要: The present invention relates to cationic compounds of formula (I) for use as peripheral NMDA receptor antagonists.
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公开(公告)号:EP3328826B1
公开(公告)日:2020-02-26
申请号:EP16744734.1
申请日:2016-07-26
申请人: INSERM - Institut National de la Santé et de la Recherche Médicale , Assistance Publique-Hôpitaux de Paris , Centre National de la Recherche Scientifique (CNRS) , Université Paris-Sud
发明人: HUMBERT, Marc , COHEN-KAMINSKY, Sylvia , DUMAS, Sébastien , BRU-MERCIER, Gilles , ALAMI, Mouad , BRION, Jean-Daniel , MESSAOUDI, Samir , GALVANI, Gilles
IPC分类号: C07C211/62 , C07C211/63
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公开(公告)号:EP3468969A1
公开(公告)日:2019-04-17
申请号:EP17729140.8
申请日:2017-06-13
申请人: Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Université Paris-Sud , Assistance Publique-Hôpitaux de Paris (APHP) , Hopital Marie Lannelongue
发明人: COHEN-KAMINSKY, Sylvia , HUMBERT, Marc , DUMAS, Sébastien , BRU-MERCIER, Gilles , MESSAOUDI, Samir , BRION, Jean-Daniel , ALAMI, Mouad , GALVANI, Gilles
IPC分类号: C07D451/02 , A61P11/00
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公开(公告)号:EP3468969B1
公开(公告)日:2020-08-05
申请号:EP17729140.8
申请日:2017-06-13
申请人: Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Université Paris-Saclay , Assistance Publique-Hôpitaux de Paris (APHP) , Hopital Marie Lannelongue
发明人: COHEN-KAMINSKY, Sylvia , HUMBERT, Marc , DUMAS, Sébastien , BRU-MERCIER, Gilles , MESSAOUDI, Samir , BRION, Jean-Daniel , ALAMI, Mouad , GALVANI, Gilles
IPC分类号: C07D451/02 , A61P11/00
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公开(公告)号:EP2274623A1
公开(公告)日:2011-01-19
申请号:EP09742310.7
申请日:2009-04-10
发明人: MOUTHON, Luc , HUMBERT, Marc , TAMBY, Mathieu
IPC分类号: G01N33/68
CPC分类号: G01N33/6854 , G01N33/6893 , G01N2800/12 , G01N2800/321 , G01N2800/52 , G01N2800/56
摘要: The invention relates to an in vitro method for detecting pulmonary arterial hypertension (PAHT), or the risk of developing PAHT, which includes determining the presence and/or amount of anti-tenascin C antibodies in a biological sample from a patient.
摘要翻译: 本发明涉及用于检测肺动脉高压(PAHT)或发展PAHT的风险的体外方法,其包括确定来自患者的生物样品中抗腱生蛋白C抗体的存在和/或量。
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公开(公告)号:EP2274623B1
公开(公告)日:2011-10-12
申请号:EP09742310.7
申请日:2009-04-10
发明人: MOUTHON, Luc , HUMBERT, Marc , TAMBY, Mathieu
IPC分类号: G01N33/68
CPC分类号: G01N33/6854 , G01N33/6893 , G01N2800/12 , G01N2800/321 , G01N2800/52 , G01N2800/56
摘要: The invention relates to an in vitro method for detecting pulmonary arterial hypertension (PAHT), or the risk of developing PAHT, which includes determining the presence and/or amount of anti-tenascin C antibodies in a biological sample from a patient.
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7.PROCÉDÉ DE DIAGNOSTIC D'UNE SCLÉRODERMIE SYSTÉMIQUE OU D'UNE HYPERTENSION ARTÉRIELLE PULMONAIRE 有权
标题翻译: 方法的硬斑病的诊断或治疗肺动脉高压公开(公告)号:EP2342566B1
公开(公告)日:2015-01-28
申请号:EP09748405.9
申请日:2009-09-17
发明人: MOUTHON, Luc , HUMBERT, Marc , CALZAS, Cynthia , CAMOIN, Luc , SAHBATOU, Younes
IPC分类号: G01N33/564
CPC分类号: G01N33/6893 , G01N33/564 , G01N2333/47 , G01N2800/10 , G01N2800/321
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8.PROCÉDÉ DE DIAGNOSTIC D'UNE SCLÉRODERMIE SYSTÉMIQUE OU D'UNE HYPERTENSION ARTÉRIELLE PULMONAIRE 有权
标题翻译: 方法用于诊断或硬斑病肺动脉高压公开(公告)号:EP2342566A1
公开(公告)日:2011-07-13
申请号:EP09748405.9
申请日:2009-09-17
发明人: MOUTHON, Luc , HUMBERT, Marc , CALZAS, Cynthia , CAMOIN, Luc , SAHBATOU, Younes
IPC分类号: G01N33/564
CPC分类号: G01N33/6893 , G01N33/564 , G01N2333/47 , G01N2800/10 , G01N2800/321
摘要: The invention relates to an
in vitro method for detecting systemic scleroderma (SSc) and/or pulmonary arterial hypertension (PAH), or a risk of developing SSc or PAH, which comprises determining the presence and/or the amount of antibodies in a biological sample originating from a patient.
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