专利检索 ap:("INSERM - Institut National de la Santé et de la Recherche Médicale" OR "CEA" OR "Université Paris Sud") AND inv:"DUFOUR, Noëlle" 第 1 页

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发明公开
LENTIVIRAL VECTORS HAVING A MUTATED INTEGRASE PROTEIN AND USES THEREOF 审中-公开
标题翻译：与突变的慢病毒载体及其应用整合

公开(公告)号：EP3046930A1

公开(公告)日：2016-07-27

申请号：EP14766503.8

申请日：2014-09-17

申请人： INSERM - Institut National de la Santé et de la Recherche Médicale , CEA , Université Paris Sud

发明人： SERGUERA, Ché , LACHAPELLE, François , DUFOUR, Noëlle , SAEED, Muhammad Qamar

IPC分类号： C07K14/005 , C12N15/86

CPC分类号： C12N15/86 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N9/1241 , C12N15/64 , C12N2740/16043 , C12N2740/16052 , C12N2740/16062 , C12N2740/16211 , C12N2800/30 , C12N2810/6081 , C12Y207/07

摘要： The present invention relates to a lentiviral vector wherein the expressed integrase protein comprises at least one point mutation consisting of the substitution of the aspartic acid residue at position 167 by an amino acid selected from the group consisting of histidine, arginine and lysine.