公开(公告)号：EP2570408A4

公开(公告)日：2013-11-13

申请号：EP11780054

申请日：2011-05-16

申请人： INST PHARM & TOXICOLOGY AMMS

发明人： LI SONG ,  ZHONG WU ,  LIU JUAN ,  WANG LILI ,  HE KUNLUN ,  LONG LONG ,  XIAO JUNHAI ,  ZHENG ZHIBING ,  LI WEI ,  LI XIN ,  HU GUOLIANG

IPC分类号： C07D295/03 ,  A61K31/17 ,  A61K31/5375 ,  A61P9/04 ,  A61P9/10 ,  A61P25/28 ,  A61P31/12 ,  C07C275/20 ,  C07C335/10

CPC分类号： C07D295/215 ,  C07D295/194

摘要： The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof; to a composition comprising a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluent; and also to use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, or preventing or treating a disease or disorder associated with apoptosis; and especially use for protecting cardiomyocyte, or preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.

摘要翻译： 本发明涉及式I化合物或其异构体，药学上可接受的盐和溶剂合物; 涉及包含式I化合物或其异构体，药学上可接受的盐和溶剂化物以及药学上可接受的载体，赋形剂或稀释剂的组合物; 以及使用式I化合物或其异构体，药学上可接受的盐和溶剂化物来防治凋亡，或预防或治疗与凋亡相关的疾病或病症; 特别是用于保护心肌细胞，或预防或治疗与心肌细胞凋亡相关的疾病或病症。