公开(公告)号：EP1386908A4

公开(公告)日：2006-07-12

申请号：EP02716048

申请日：2002-01-21

申请人： INST PHARM & TOXICOLOGY AMMS

发明人： WANG HAI ,  YANG RIFANG ,  LONG CHAOLIANG ,  YUN LIUHONG ,  CUI WENYU ,  WANG LIN ,  FENG HUASONG ,  GAO QIXIU ,  LU XINQIANG ,  LI FULIN ,  HU GANG ,  LIU LIJUN ,  TANG XINGCHUN ,  ZHAO RUSHENG ,  YAN YUAN ,  HE HUAMEI ,  LIU WEI

IPC分类号： A61K31/13 ,  A61K31/131 ,  A61K31/132 ,  A61K31/136 ,  A61K31/137 ,  A61K31/16 ,  A61K31/165 ,  A61K31/18 ,  A61K31/405 ,  A61K31/455 ,  A61P1/06 ,  A61P3/10 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/06 ,  A61P17/12 ,  A61P25/00 ,  A61P25/08 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07B61/00 ,  C07C209/04 ,  C07C209/28 ,  C07C211/08 ,  C07C211/09 ,  C07C211/17 ,  C07C211/21 ,  C07C211/27 ,  C07C213/04 ,  C07C215/08 ,  C07C231/02 ,  C07C233/11 ,  C07C235/34 ,  C07C237/06 ,  C07C237/20 ,  C07C243/02 ,  C07C303/38 ,  C07C311/16 ,  C07D209/20 ,  C07D213/82 ,  C07C209/18 ,  C07C211/18 ,  C07C215/00 ,  C07C229/06 ,  C07C233/64 ,  C07C311/17 ,  C07D233/44 ,  C07D263/28 ,  C07D295/15

CPC分类号： C07D213/82 ,  A61K31/13 ,  C07C211/08

摘要： The present invention relates to an amine derivative of formula I, its isomer, racemate or optical isomer, pharmaceutical salt, its amide or ester, a medicinal composition containing these, and the preparation of the same. The invention also relates to the use of these compounds in preparing medicines for preventing or treating cardiovascular diseases, diabetes, bronchus and urinary system smooth muscle convulsion, and nerve damage due to ischemia and anoxia. These compounds can be used to treat hypertension, angina, cardiac infraction, congestive heart-failure, arrhythmia, diabetes, bronchial spasm diseases, bladder or ureter spasm diseases, and depression.